TY - GEN
T1 - Direct polymerization patterning based on eb lithography for control of cell adhesive orientation
AU - Idota, N.
AU - Tsukahara, T.
AU - Hibara, A.
AU - Okano, T.
AU - Kitamori, T.
N1 - Publisher Copyright:
© 2007 CBMS.
PY - 2007
Y1 - 2007
N2 - In this study, we demonstrated a novel simple preparation process of the patterned polymer-grafted glass surfaces using electron beam (EB) lithography system without any photo-masks. N-isopropylacrylamide (NIPAAm) was locally polymerized and directly grafted onto surfaces only by single step of EB lithography. On these surfaces, cells adhered and spread with an orientation in accordance with the stripe pattern direction. When temperature decreased to 25°C, the cultured cells were detached from the surfaces and shrunken along the stripe pattern direction.
AB - In this study, we demonstrated a novel simple preparation process of the patterned polymer-grafted glass surfaces using electron beam (EB) lithography system without any photo-masks. N-isopropylacrylamide (NIPAAm) was locally polymerized and directly grafted onto surfaces only by single step of EB lithography. On these surfaces, cells adhered and spread with an orientation in accordance with the stripe pattern direction. When temperature decreased to 25°C, the cultured cells were detached from the surfaces and shrunken along the stripe pattern direction.
KW - Cell patterning cell adhesive orientation
KW - EB lithographic polymerization
KW - Thermoresponsive surface
UR - http://www.scopus.com/inward/record.url?scp=85088680734&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85088680734&partnerID=8YFLogxK
M3 - Conference contribution
AN - SCOPUS:85088680734
T3 - Proceedings of the 11th International Conference on Miniaturized Systems for Chemistry and Life Sciences, uTAS 2007
SP - 430
EP - 432
BT - Proceedings of the 11th International Conference on Miniaturized Systems for Chemistry and Life Sciences, uTAS 2007
A2 - Viovy, Jean-Louis
A2 - Tabeling, Patrick
A2 - Descroix, Stephanie
A2 - Malaquin, Laurent
PB - Chemical and Biological Microsystems Society
T2 - 11th International Conference on Miniaturized Systems for Chemistry and Life Sciences, uTAS 2007
Y2 - 7 October 2007 through 11 October 2007
ER -