Discovery of a Cyclic Depsipeptide from Chaetomium mollipilium by the Genome Mining Approach

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Abstract

Genome mining and bioinformatics analyses allowed us to rationally find a candidate biosynthetic gene cluster for a new cyclic depsipeptide of Chaetomium mollipilium. A heterologous reconstitution of the identified biosynthetic pathway predictably afforded a new cyclic depsipeptide composed of L-leucine, L-tryptophan, and a polyketide moiety. Interestingly, the 10-membered macrocycle structure generated equilibrium to an unprecedented cyclol structure. This study demonstrates the advantage of a synthetic biology method in achieving rational access to new natural products.

Original languageEnglish
Pages (from-to)3504-3509
Number of pages6
JournalOrganic Letters
Volume24
Issue number19
DOIs
Publication statusPublished - 2022 May 20

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