Dissecting human adrenal androgen production

William E. Rainey, Bruce R. Carr, Hironobu Sasano, Takashi Suzuki, J. Ian Mason

Research output: Contribution to journalReview articlepeer-review

221 Citations (Scopus)


The human adrenal cortex produces aldosterone, cortisol and the so-called adrenal androgens, dehydroepiandrosterone (DHEA) and DHEA sulfate (DHEAS). Within the adult adrenal, the zona glomerulosa produces aldosterone, the zona fasciculata cortisol and the zona reticularis both DHEA and DHEAS. The processes regulating aldosterone and cortisol synthesis are well defined; however, the mechanisms regulating the production of DHEA(S) remain elusive. The emphasis of this review is based on increasing evidence that cytochrome b5, DHEA sulfotransferase and 3β hydroxysteroid dehydrogenase play crucial roles in regulating production of DHEA(S). Insight into the mechanisms that regulate the synthesis of these key components of DHEA(S) synthesis should provide important clues to the regulation of adrenal androgen biosynthesis.

Original languageEnglish
Pages (from-to)234-239
Number of pages6
JournalTrends in Endocrinology and Metabolism
Issue number6
Publication statusPublished - 2002 Aug


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