Dissociable roles of prefrontal and anterior cingulate cortices in deception

Nobuhito Abe, Maki Suzuki, Takashi Tsukiura, Etsuro Mori, Keiichiro Yamaguchi, Masatoshi Itoh, Toshikatsu Fujii

Research output: Contribution to journalArticlepeer-review

121 Citations (Scopus)


Recent neuroimaging studies have shown the importance of the prefrontal and anterior cingulate cortices in deception. However, little is known about the role of each of these regions during deception. Using positron emission tomography (PET), we measured brain activation while participants told truths or lies about two types of real-world events: experienced and unexperienced. The imaging data revealed that activity of the dorsolateral, ventrolateral and medial prefrontal cortices was commonly associated with both types of deception (pretending to know and pretending not to know), whereas activity of the anterior cingulate cortex (ACC) was only associated with pretending not to know. Regional cerebral blood flow (rCBF) increase in the ACC was positively correlated with that in the dorsolateral prefrontal cortex only during pretending not to know. These results suggest that the lateral and medial prefrontal cortices have general roles in deception, whereas the ACC contributes specifically to pretending not to know.

Original languageEnglish
Pages (from-to)192-199
Number of pages8
JournalCerebral Cortex
Issue number2
Publication statusPublished - 2006 Feb


  • Executive function
  • Frontal lobe
  • Lie detection
  • PET
  • Social interactions

ASJC Scopus subject areas

  • Cognitive Neuroscience
  • Cellular and Molecular Neuroscience


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