Distribution of prion protein in German patients with Creutzfeldt-Jakob disease is different from that in Japanese patients

R. Doi-Yi; T. Kitamoto; K. Ogomori; P. Mehraein; J. Tateishi

doi:10.1007/BF00294174

Distribution of prion protein in German patients with Creutzfeldt-Jakob disease is different from that in Japanese patients

R. Doi-Yi, T. Kitamoto, K. Ogomori, P. Mehraein, J. Tateishi

Research output: Contribution to journal › Article › peer-review

8 Citations (Scopus)

Abstract

We investigated the distribution of prion protein (PrP) in 14 German patients with sporadic Creutzfeldt-Jakob disease (CJD) and compared it with that observed in Japanese patients. Immunohistochemical study revealed diffuse gray matter stainings including synaptic structures in all cases. In addition, 4 patients showed plaque-type deposition which was very rarely observed among sporadic Japanese patients without known mutation of the PrP gene but with valine at codon 129. A higher incidence of PrP plaques in German sporadic CJD may be related to the racial difference in the PrP gene.

Original language	English
Pages (from-to)	481-483
Number of pages	3
Journal	Acta neuropathologica
Volume	87
Issue number	5
DOIs	https://doi.org/10.1007/BF00294174
Publication status	Published - 1994 May 1
Externally published	Yes

Keywords

Creutzfeld-Jakob disease (CJD)
Genotypes
Gerstmann-Sträussler-Scheinker syndrome (GSS)
Phenotypes
Prion protein (PrP)

ASJC Scopus subject areas

Pathology and Forensic Medicine
Clinical Neurology
Cellular and Molecular Neuroscience

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title = "Distribution of prion protein in German patients with Creutzfeldt-Jakob disease is different from that in Japanese patients",

abstract = "We investigated the distribution of prion protein (PrP) in 14 German patients with sporadic Creutzfeldt-Jakob disease (CJD) and compared it with that observed in Japanese patients. Immunohistochemical study revealed diffuse gray matter stainings including synaptic structures in all cases. In addition, 4 patients showed plaque-type deposition which was very rarely observed among sporadic Japanese patients without known mutation of the PrP gene but with valine at codon 129. A higher incidence of PrP plaques in German sporadic CJD may be related to the racial difference in the PrP gene.",

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AU - Doi-Yi, R.

AU - Kitamoto, T.

AU - Ogomori, K.

AU - Mehraein, P.

AU - Tateishi, J.

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AB - We investigated the distribution of prion protein (PrP) in 14 German patients with sporadic Creutzfeldt-Jakob disease (CJD) and compared it with that observed in Japanese patients. Immunohistochemical study revealed diffuse gray matter stainings including synaptic structures in all cases. In addition, 4 patients showed plaque-type deposition which was very rarely observed among sporadic Japanese patients without known mutation of the PrP gene but with valine at codon 129. A higher incidence of PrP plaques in German sporadic CJD may be related to the racial difference in the PrP gene.

KW - Creutzfeld-Jakob disease (CJD)

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KW - Gerstmann-Sträussler-Scheinker syndrome (GSS)

KW - Phenotypes

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Distribution of prion protein in German patients with Creutzfeldt-Jakob disease is different from that in Japanese patients

Abstract

Keywords

ASJC Scopus subject areas

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