TY - JOUR
T1 - Distribution of Tsc2 protein in various normal rat tissues and renal tumours of Tsc2 mutant (Eker) rat detected by immunohistochemistry
AU - Fukuda, Tomokazu
AU - Kobayashi, Toshiyuki
AU - Yasui, Hideaki
AU - Tsutsumi, Masahiro
AU - Konishi, Yoichi
AU - Hino, Okio
N1 - Funding Information:
&p.2: wledgements This work was supported in part by a Grant-in-Aid for Cancer Research from the Ministry of Education, Science, Sports and Culture of Japan and the Organization for Pharmaceutical Safety and Research (OPSR). We thank Dr. K. Nishida (Saitama Cancer center, Japan) and Dr. M. Yoshida (Sasaki Institute, Japan) for special advice for histopathological judgment. We thank Ms. K. Nomura (Cancer Institute, Department of Pathology) for technical advice regarding immunostaining. We also thank Drs. H Sugano, T. Kitagawa and A.G. Knudson for their encouragement throughout this work.
PY - 1999
Y1 - 1999
N2 - Alterations in the rat tuberous sclerosis gene (Tsc2) are responsible for the hereditary renal carcinomas (RCs) of Eker rat. We examined protein distribution in various normal rat tissues and the Eker RCs by immunohistochemistry. Tsc2 protein is expressed in the mammary ducts, salivary glands, gastric glands, parathyroid, small and large intestine, ovary and uterus. Specific expression of Tsc2 protein is found in the B cells of pancreatic islets and in the smooth muscle of lung veins. Interestingly, in the RCs of Eker rat, TsC2 protein was detectable with some variation in reactivity.
AB - Alterations in the rat tuberous sclerosis gene (Tsc2) are responsible for the hereditary renal carcinomas (RCs) of Eker rat. We examined protein distribution in various normal rat tissues and the Eker RCs by immunohistochemistry. Tsc2 protein is expressed in the mammary ducts, salivary glands, gastric glands, parathyroid, small and large intestine, ovary and uterus. Specific expression of Tsc2 protein is found in the B cells of pancreatic islets and in the smooth muscle of lung veins. Interestingly, in the RCs of Eker rat, TsC2 protein was detectable with some variation in reactivity.
KW - Eker rat
KW - Renal cell carcinoma
KW - Tsc2 protein
KW - Tuberous sclerosis
UR - http://www.scopus.com/inward/record.url?scp=0032945097&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0032945097&partnerID=8YFLogxK
U2 - 10.1007/s004280050350
DO - 10.1007/s004280050350
M3 - Article
C2 - 10335945
AN - SCOPUS:0032945097
SN - 0945-6317
VL - 434
SP - 341
EP - 350
JO - Virchows Archiv - Abteilung A Pathologische Anatomie
JF - Virchows Archiv - Abteilung A Pathologische Anatomie
IS - 4
ER -