Divergent synthesis of sialylated glycan chains: Combined use of polymer support, resin capture-release, and chemoenzymatic strategies

Shinya Hanashima; Shino Manabe; Yukishige Ito

doi:10.1002/anie.200500777

Divergent synthesis of sialylated glycan chains: Combined use of polymer support, resin capture-release, and chemoenzymatic strategies

Shinya Hanashima, Shino Manabe, Yukishige Ito

PHA - Graduate School of Pharmaceutical Sciences (department affiliation only)

Research output: Contribution to journal › Article › peer-review

45 Citations (Scopus)

Abstract

(Chemical Equation Presented) Carbo loading! The synthesis of α(2,3)- or α(2,6)-sialylated biantennary glycans is possible with a new approach. The common precursor 1 was synthesized with a soluble polymer support strategy (a) in combination with a resin capture-release protocol. Hexasaccharide 1 can then be diverged to various polysaccharides by enzymatic glycosylation (b). Bn = benzyl, TBS = tert-butyldimethylsilyl.

Original language	English
Pages (from-to)	4218-4224
Number of pages	7
Journal	Angewandte Chemie - International Edition
Volume	44
Issue number	27
DOIs	https://doi.org/10.1002/anie.200500777
Publication status	Published - 2005 Jul 4

Keywords

Carbohydrates
Glycoproteins
Glycosylation
Oligosaccharides
Sialic acids

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10.1002/anie.200500777

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abstract = "(Chemical Equation Presented) Carbo loading! The synthesis of α(2,3)- or α(2,6)-sialylated biantennary glycans is possible with a new approach. The common precursor 1 was synthesized with a soluble polymer support strategy (a) in combination with a resin capture-release protocol. Hexasaccharide 1 can then be diverged to various polysaccharides by enzymatic glycosylation (b). Bn = benzyl, TBS = tert-butyldimethylsilyl.",

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KW - Glycoproteins

KW - Glycosylation

KW - Oligosaccharides

KW - Sialic acids

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Divergent synthesis of sialylated glycan chains: Combined use of polymer support, resin capture-release, and chemoenzymatic strategies

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Keywords

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