Dlx-dependent and -independent regulation of olfactory bulb interneuron differentiation

Jason E. Long, Sonia Garel, Manuel Alvarez-Dolado, Kazuaki Yoshikawa, Noriko Osumi, Arturo Alvarez-Buylla, John L.R. Rubenstein

Research output: Contribution to journalArticlepeer-review

115 Citations (Scopus)


Olfactory bulb interneuron development is a complex multistep process that involves cell specification in the ventral telencephalon, tangential migration into the olfactory bulb, and local neuronal maturation. Although several transcription factors have been implicated in this process, how or when they act remains to be elucidated. Here we explore the mechanisms that result in olfactory bulb interneuron defects in Dlx1&2-/- (distal-less homeobox 1 and 2) and Mash1-/- (mammalian achaete-schute homolog 1) mutants. We provide evidence that Dlx1&2 and Mash1 regulate parallel molecular pathways that are required for the generation of these cells, thereby providing new insights into the mechanisms underlying olfactory bulb development. The analysis also defined distinct anatomical zones related to olfactory bulb development. Finally we show that Dlx1&2 are required for promoting tangential migration to the olfactory bulb, potentially via regulating the expression of ErbB4 (v-erb-a erythroblastic leukemia viral oncogene homolog 4), Robo2 (roundabout homolog 2), Slit1 (slit homolog 1), and PK2 (prokineticin 2), which have all been shown to play essential roles in this migration.

Original languageEnglish
Pages (from-to)3230-3243
Number of pages14
JournalJournal of Neuroscience
Issue number12
Publication statusPublished - 2007 Mar 21


  • Development
  • Forebrain
  • GABA
  • Interneuron
  • Migration
  • Olfactory bulb


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