DNA cleaving activities of 9-membered masked enediyne analogues possessing DNA intercalator and sugar moieties

Takashi Takahashi; Hiroshi Tanaka; Akihisa Matsuda; Takayuki Doi; Haruo Yamada; Takuyuki Matsumoto; Daisuke Sasaki; Yukio Sugiura

doi:10.1016/S0960-894X(98)00606-4

DNA cleaving activities of 9-membered masked enediyne analogues possessing DNA intercalator and sugar moieties

Takashi Takahashi, Hiroshi Tanaka, Akihisa Matsuda, Takayuki Doi, Haruo Yamada, Takuyuki Matsumoto, Daisuke Sasaki, Yukio Sugiura

PHA - Molecular Pharmaceutical Science

Research output: Contribution to journal › Article › peer-review

16 Citations (Scopus)

Abstract

The DNA cleaving properties of various enediyne analogues possessing sugar moieties and DNA-intercalators were investigated. The DNA cleaving experiments show that these hybrids analogues induced sequence-selective DNA cleavage and the simple sugars in the enediyne serve as a DNA recognition element for DNA cleavage.

Original language	English
Pages (from-to)	3303-3306
Number of pages	4
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	8
Issue number	23
DOIs	https://doi.org/10.1016/S0960-894X(98)00606-4
Publication status	Published - 1998 Dec 1

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10.1016/S0960-894X(98)00606-4

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title = "DNA cleaving activities of 9-membered masked enediyne analogues possessing DNA intercalator and sugar moieties",

abstract = "The DNA cleaving properties of various enediyne analogues possessing sugar moieties and DNA-intercalators were investigated. The DNA cleaving experiments show that these hybrids analogues induced sequence-selective DNA cleavage and the simple sugars in the enediyne serve as a DNA recognition element for DNA cleavage.",

author = "Takashi Takahashi and Hiroshi Tanaka and Akihisa Matsuda and Takayuki Doi and Haruo Yamada and Takuyuki Matsumoto and Daisuke Sasaki and Yukio Sugiura",

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AU - Takahashi, Takashi

AU - Tanaka, Hiroshi

AU - Matsuda, Akihisa

AU - Doi, Takayuki

AU - Yamada, Haruo

AU - Matsumoto, Takuyuki

AU - Sasaki, Daisuke

AU - Sugiura, Yukio

PY - 1998/12/1

Y1 - 1998/12/1

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AB - The DNA cleaving properties of various enediyne analogues possessing sugar moieties and DNA-intercalators were investigated. The DNA cleaving experiments show that these hybrids analogues induced sequence-selective DNA cleavage and the simple sugars in the enediyne serve as a DNA recognition element for DNA cleavage.

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ER -

DNA cleaving activities of 9-membered masked enediyne analogues possessing DNA intercalator and sugar moieties

Abstract

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