TY - JOUR
T1 - DNA repair protein XPA binds replication protein A (RPA)
AU - Matsuda, T.
AU - Saijo, M.
AU - Kuraoka, I.
AU - Kobayashi, T.
AU - Nakatsu, Y.
AU - Nagai, A.
AU - Enjoji, T.
AU - Masutani, C.
AU - Sugasawa, K.
AU - Hanaoka, F.
AU - Yasui, A.
AU - Tanaka, K.
PY - 1995
Y1 - 1995
N2 - XPA is a zinc finger DNA-binding protein, which is missing or altered in group A xeroderma pigmentosum cells and known to be involved in the damage- recognition step of the nucleotide excision repair (NER) processes. Using the yeast two-hybrid system to search for proteins that interact with XPA, we obtained the 34-kDa subunit of replication protein A (RPA, also known as HSSB and RFA). RPA is a stable complex of three polypeptides of 70, 34, 11 kDa and has been shown to be essential in the early steps of NER as well as in replication and recombination. We also demonstrate here that the RPA complex associates with XPA. These results suggest that RPA may cooperate with XPA in the early steps of the NER processes.
AB - XPA is a zinc finger DNA-binding protein, which is missing or altered in group A xeroderma pigmentosum cells and known to be involved in the damage- recognition step of the nucleotide excision repair (NER) processes. Using the yeast two-hybrid system to search for proteins that interact with XPA, we obtained the 34-kDa subunit of replication protein A (RPA, also known as HSSB and RFA). RPA is a stable complex of three polypeptides of 70, 34, 11 kDa and has been shown to be essential in the early steps of NER as well as in replication and recombination. We also demonstrate here that the RPA complex associates with XPA. These results suggest that RPA may cooperate with XPA in the early steps of the NER processes.
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U2 - 10.1074/jbc.270.8.4152
DO - 10.1074/jbc.270.8.4152
M3 - Article
C2 - 7876167
AN - SCOPUS:0028942129
SN - 0021-9258
VL - 270
SP - 4152
EP - 4157
JO - Journal of Biological Chemistry
JF - Journal of Biological Chemistry
IS - 8
ER -