TY - JOUR
T1 - Dopaminergic drug-induced jaw-opening dystonia in a patient with progressive supranuclear palsy
AU - Tano, Ohito
AU - Kaneko, Kimihiko
AU - Kikuchi, Akio
AU - Hasegawa, Takafumi
AU - Takeda, Atsushi
AU - Aoki, Masashi
PY - 2013/4
Y1 - 2013/4
N2 - A 74 year-old man with progressive supranuclear palsy (PSP) was adimitted to our hospital. He developed bradykinesia 13 years previously. Neurological examination showed cognitive dysfunction, supranuclear vertical gaze palsy, pseudobulbar palsy, and parkinsonism such as akinesia, rigidity, and resting tremor. His chief complaint was glossoptosis with jaw-opening dystonia associated with rapid dose-elevation and/or overdose of dopaminergic drugs. After gradual tapering of dopaminergic drugs, he could keep his mouth closed all day. Drug-induced dystonia is a frequently encountered but often overlooked symptom of neurological disorders. The motor symptoms of PSP sometimes respond to dopamine replacement therapy; however, it should be kept in mind that rapid dose-elevation and/or overdose of dopaminergic agents may cause jaw-opening dystonia.
AB - A 74 year-old man with progressive supranuclear palsy (PSP) was adimitted to our hospital. He developed bradykinesia 13 years previously. Neurological examination showed cognitive dysfunction, supranuclear vertical gaze palsy, pseudobulbar palsy, and parkinsonism such as akinesia, rigidity, and resting tremor. His chief complaint was glossoptosis with jaw-opening dystonia associated with rapid dose-elevation and/or overdose of dopaminergic drugs. After gradual tapering of dopaminergic drugs, he could keep his mouth closed all day. Drug-induced dystonia is a frequently encountered but often overlooked symptom of neurological disorders. The motor symptoms of PSP sometimes respond to dopamine replacement therapy; however, it should be kept in mind that rapid dose-elevation and/or overdose of dopaminergic agents may cause jaw-opening dystonia.
KW - Dopaminergic drug-induced dystonia
KW - Jaw-opening dystonia
KW - Oromandibular dystonia
KW - Progressive supranuclear palsy
UR - http://www.scopus.com/inward/record.url?scp=84876360236&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84876360236&partnerID=8YFLogxK
U2 - 10.5692/clinicalneurol.53.308
DO - 10.5692/clinicalneurol.53.308
M3 - Article
C2 - 23603547
AN - SCOPUS:84876360236
SN - 0009-918X
VL - 53
SP - 308
EP - 311
JO - Clinical Neurology
JF - Clinical Neurology
IS - 4
ER -