Double Functionalization of Styrenes by Cu-Mediated Assisted Tandem Catalysis

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The double functionalization of styrenes through Cu-mediated assisted tandem catalysis was developed. The reaction was initiated by Cu-catalyzed aziridination and the subsequent nucleophilic ring-opening, which was triggered by the addition of (NH 4 ) 2 S 2 O 8 as an oxidant of Cu-catalyst to form a variety of C–C and C–X bonds. The expansion to three contiguous catalytic cycles led to the synthesis of functionalized indolines by one-pot operation.

Original languageEnglish
Pages (from-to)2056-2060
Number of pages5
JournalEuropean Journal of Organic Chemistry
Issue number10
Publication statusPublished - 2019 Mar 14


  • Cu-catalysis
  • Double functionalization
  • Indolines
  • Spirocycle
  • Tandem catalysis


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