TY - JOUR
T1 - Drug delivery devices for retinal diseases
AU - Kaji, Hirokazu
AU - Nagai, Nobuhiro
AU - Nishizawa, Matsuhiko
AU - Abe, Toshiaki
N1 - Funding Information:
This work was partially supported by Grants-in-Aid for Scientific Research (B) ( 26286031 and 17H02752 ) and for Challenging Exploratory Research (16K12890) from the Ministry of Education, Culture, Sports, Science and Technology (MEXT), Japan, by Grants ( 15ek0109073h0001 and 16ek0109073h0002 ) from the Japan Agency for Medical Research and Development (AMED), and by the Grant for Basic Science and Platform Technology Program for Innovative Biological Medicine from AMED .
Publisher Copyright:
© 2017 Elsevier B.V.
PY - 2018/3/15
Y1 - 2018/3/15
N2 - Retinal degenerative diseases are a leading cause of irreversible blindness and visual impairment, affecting millions of people worldwide. Although intravitreal injection can directly deliver drugs to the posterior segment of the eye, it is invasive and associated with serious side effects. The design of drug delivery systems targeting the posterior segment of the eye in a less invasive manner has still been challenging because of various anatomical and physiological barriers. In this review, we provide an overview of the current implant device-based approaches used for treating retinal degenerative diseases. We then offer our perspectives on future directions and challenges that remain for developing more effective device-based therapies for retinal diseases.
AB - Retinal degenerative diseases are a leading cause of irreversible blindness and visual impairment, affecting millions of people worldwide. Although intravitreal injection can directly deliver drugs to the posterior segment of the eye, it is invasive and associated with serious side effects. The design of drug delivery systems targeting the posterior segment of the eye in a less invasive manner has still been challenging because of various anatomical and physiological barriers. In this review, we provide an overview of the current implant device-based approaches used for treating retinal degenerative diseases. We then offer our perspectives on future directions and challenges that remain for developing more effective device-based therapies for retinal diseases.
KW - Biodegradable
KW - Intraocular implants
KW - Non-biodegradable
KW - Periocular implants
KW - Posterior segment of the eye
KW - Transscleral route
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U2 - 10.1016/j.addr.2017.07.002
DO - 10.1016/j.addr.2017.07.002
M3 - Review article
C2 - 28690136
AN - SCOPUS:85023169449
SN - 0169-409X
VL - 128
SP - 148
EP - 157
JO - Advanced Drug Delivery Reviews
JF - Advanced Drug Delivery Reviews
ER -