Derivatives of pterin, an important cofactor for neuronal nitric oxide synthase, markedly changed the kinetics of CO binding to the enzyme-bound heme. In the absence of the substrate, L-Arg, CO binding was dependent on the CO concentration for pterin complexes, whereas in the presence of L-Arg, it became CO-independent for most pterin complexes. This suggests dual effects of substrate and pterin binding on the kinetics and access of CO to the ligand channel.
|Number of pages||2|
|Publication status||Published - 2005 Jun 5|
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