Dynamic changes in expression of heme oxygenases in mouse heart and liver during hypoxia

Feng Han, Kazuhisa Takeda, Satoru Yokoyama, Hideo Ueda, Yotaro Shinozawa, Kazumichi Furuyama, Shigeki Shibahara

Research output: Contribution to journalArticlepeer-review

25 Citations (Scopus)


Heme oxygenase cleaves heme to form biliverdin, carbon monoxide (CO), and iron, and consists of two structurally related isozymes, HO-1 and HO-2. HO-2 is also known as a potential oxygen sensor. Here we show that the relative CO content in arterial blood, which reflects the total amount of endogenous heme degradation, dynamically changes in mice during acclimatization to normobaric hypoxia (10% O2), with the two peaks at 1 day and 21 days of hypoxia. The expression levels of HO-1 and HO-2 proteins were decreased by 20% and 40%, respectively, in the mouse liver at 7 days of hypoxia, which returned to the basal levels at 14 days. On the other hand, HO-1 and HO-2 proteins were increased 2-fold and 1.3-fold, respectively, in the heart at 28 days of hypoxia. Thus, hypoxia induces or represses the expression of HO-1 and HO-2 in vivo, depending on cellular microenvironments.

Original languageEnglish
Pages (from-to)653-659
Number of pages7
JournalBiochemical and biophysical research communications
Issue number1
Publication statusPublished - 2005 Dec 9
Externally publishedYes


  • Bilirubin
  • Carbon monoxide
  • Heart
  • Heme oxygenase
  • Hypoxia
  • Liver
  • Oxygen sensor

ASJC Scopus subject areas

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology


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