Early-infant diagnostic predictors of the neuro-behavioral development after neonatal care

Mamiko Koshiba, Hiroko Kakei, Masakazu Honda, Genta Karino, Mamoru Niitsu, Toru Miyaji, Hirohisa Kishino, Shun Nakamura, Tetsuya Kunikata, Hideo Yamanouchi

Research output: Contribution to journalArticlepeer-review

7 Citations (Scopus)


Multidimensional diagnosis plays a central role in infant developmental care, which leads to the prediction of future disabilities. Information consolidated from objective and subjective, early and late, central and peripheral data may reveal neuro-pathological mechanisms and realize earlier and more precise preventive intervention.In the current study, we retrospectively searched correlating factors to the following neurological and behavioral development of 'Head Control' and 'Roll Over' using multivariate correlation analysis of different diagnostic domains over age, subject/object information of the patients who were previously admitted in our neonatal intensive care unit (NICU) and could be developmentally followed up in our outpatient clinic. Based on the hematologic and biochemical data, MRI brain anatomy during NICU hospitalization, we characterized all the acquired data distribution from 31 infants with either 'appeared neurologically normal (ANN, n=. 21)' or 'appeared neurologically abnormal (ANA, n = 10)' pro tempore, with a physician's clinical judgment before discharge. Besides single factor comparisons between ANN and ANA, we examined their development difference by using the multidimensional information processing, principal component analysis (PCA). The diagnostic predictors of neuro-behavioral development were selected by regression analysis with variable selection. It resulted that hematological and brain anatomical factors seemed correlated to both 'Head Control' and 'Roll Over'. This report suggested certain possibility of the cross-domain translational approach between subjective and objective developmental information through multivariate analyses, with candidate markers preliminarily to be evaluated in further studies.

Original languageEnglish
Pages (from-to)143-150
Number of pages8
JournalBehavioural Brain Research
Publication statusPublished - 2015 Jan 1


  • Developmental milestone
  • Hematologic factor
  • Multivariate correlation analysis
  • Predictive diagnosis
  • T1-weighted brain MRI metric
  • Voluntary behavior against gravity


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