Effect of a comprehensive lifestyle modification program on the bone density of male heavy drinkers

Toshifumi Matsui, Akira Yokoyama, Sachio Matsushita, Ryuichi Ogawa, Shuka Mori, Emiko Hayashi, Sungwon Roh, Susumu Higuchi, Hiroyuki Arai, Katsuya Maruyama

Research output: Contribution to journalArticlepeer-review

14 Citations (Scopus)


Background: Heavy alcohol drinking is implicated in osteoporosis. Although abstinence is rapidly followed by a restoration of osteoblastic activity, little is known about the contributions of alcohol-related factors or the effectiveness of a lifestyle modification program (LMP) on bone density. Methods: We conducted a study of 138 male alcoholic patients to investigate whether drinking history and concurrent factors were associated with the bone density of the calcaneus. A 2.5-months LMP in an institutionalized setting was completed by 20 of them, and its effect on bone density, serum parathyroid hormone (PTH), and 1.25-(OH) 2 vitamin D levels were assessed. Results: The patients had a high prevalence of daytime drinking (93.5%), continuous drinking (84.1%), and current smoking (82.0%) with mean duration of alcohol abuse of 30.0 ± 12.8 years. The patients had lower bone density than a reference control group (Z-scores: -0.45 ± 1.02). Multiple stepwise regression analysis identified age, poor activities of daily living (ADL), continuous drinking, absence of liver cirrhosis, depression, and dementia as determinants of low bone density. The bone density of the 20 participants in the LMP improved 2.3% (p = 0.0003) with a more ameliorating effect on bone density than a conventional abstinence therapy (p = 0.014 for interventional effect). The upper normal range of PTH levels at baseline were significantly decreased, and 1.25-(OH) 2 vitamin D levels also had a trend toward decrease during the abstinence. Conclusions: Alcoholic patients may have many complications such as poor ADL and dementia, which are independently associated with decreased bone density. The results of this study support the idea that comprehensive approach to lifestyle factors to minimize risk of osteoporosis is the best way to improve bone density.

Original languageEnglish
Pages (from-to)869-875
Number of pages7
JournalAlcoholism: Clinical and Experimental Research
Issue number5
Publication statusPublished - 2010 May 1


  • Abstinence
  • Alcoholic Patients
  • Bone Density
  • Chronic Disease
  • Lifestyle Factors
  • Osteoporosis

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Toxicology
  • Psychiatry and Mental health


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