Effect of a liver X receptor agonist on deposition and lymphatic absorption of plant sterols in stroke-prone spontaneously hypertensive rats having a mutation in ATP-binding cassette transporter G5

Tadateru Hamada, Mariko Kudo, Masao Sato, Nao Inoue, Koji Nagao, Katsumi Imaizumi, Ikuo Ikeda

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    1 Citation (Scopus)

    Abstract

    The effects were compared of T0901317, a liver X receptor agonist, on deposition in the liver and serum and lymphatic absorption of plant sterols in stroke-prone spontaneously hypertensive rats (SHRSPs) having a missense mutation in Abcg5, which codes for ATP-binding cassette transporter (ABC) G5, with those in Wistar rats. Both strains were pair-fed for 7 d with a 0.5% plant sterol diet with or without 5 mg/kg of body weight of T0901317. The deposition of plant sterols in the liver and serum was higher in SHRSPs than in Wistar rats. A significant reduction of plant sterol deposition was observed in Wistar rats, but not in SHRSPs when T0901317 was given. Both strains were then fed for 7 d with a control diet with or without T0901317. The lymphatic absorption of plant sterols was reduced to almost half the normal level by the T0901317 treatment. However, no difference in absorption was apparent between SHRSPs and Wistar rats regardless of the T0901317 treatment. These results suggest that the plant sterol deposition in SHRSPs was not necessarily caused by the increased absorption of plant sterols.

    Original languageEnglish
    Pages (from-to)2359-2363
    Number of pages5
    JournalBioscience, Biotechnology and Biochemistry
    Volume75
    Issue number12
    DOIs
    Publication statusPublished - 2011

    Keywords

    • ATP-binding cassette transporter G5
    • ATPbinding cassette transporter G8
    • Campesterol
    • Liver X receptor
    • Sitosterol

    ASJC Scopus subject areas

    • Biotechnology
    • Analytical Chemistry
    • Biochemistry
    • Applied Microbiology and Biotechnology
    • Molecular Biology
    • Organic Chemistry

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