Effect of ambrisentan on peripheral circulation in patients with systemic sclerosis

Hayakazu Sumida, Yoshihide Asano, Masaru Hatano, Naohiko Aozasa, Tetsuo Toyama, Kaname Akamata, Miki Miyazaki, Takashi Taniguchi, Takehiro Takahashi, Yohei Ichimura, Shinji Noda, Yoshihiro Kuwano, Koichi Yanaba, Shinichi Sato

Research output: Contribution to journalArticlepeer-review

3 Citations (Scopus)


Systemic sclerosis (SSc) is characterized by disturbed blood circulation. The effect of ambrisentan, an endothelin-A receptor-selective antagonist, on impaired peripheral circulation in SSc remains largely elusive. Here we show SSc patients, whose clinical symptoms such as cyanosis and Raynaud's phenomenon, were ameliorated by the treatment with ambrisentan. Additionally, objective evaluations with thermography showed improvement of hand coldness in steady-state and cold challenge tests. Ambrisentan might have a potential to improve peripheral circulation in SSc.

Original languageEnglish
Pages (from-to)454-457
Number of pages4
JournalModern Rheumatology
Issue number3
Publication statusPublished - 2016 May 3


  • Ambrisentan
  • Cyanosis
  • Raynaud's phenomenon
  • Systemic sclerosis
  • Thermography


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