Effect of anions on morphology control of brushite particles

Ryo Hamai, Takeshi Toshima, Masamoto Tafu, Takaaki Masutani, Tetsuji Chohji

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

14 Citations (Scopus)


Brushite (DCPD, CaHPO4.2H2O) crystals are of great significance in a range of fields including biology, medicine, chemistry, and materials science. One important issue is the control of their morphology; when the crystal growth conditions are changed, the morphology and surface crystal conditions also change. The chemical reaction behavior depends strongly on the surface condition of the particles. Here, we report the effect of coexisting anions on the morphology control of DCPD particles. We synthesized the particles through a liquid-phase reaction by mixing a starting solution of ammonium dihydrogen phosphate (NH4H2PO4) and calcium salts. Calcium nitrate (Ca(NO3)2) and calcium acetate (Ca(CH3COO)2) were used as the calcium sources to clarify the pH dependence of the morphology. We mixed the solutions with the same pH values and agitated them, and observed the products by scanning electron microscopy (SEM) and X-ray diffraction (XRD); the DCPD morphology varies from petal-like to parallelogram structures depending on the initial pH value of the solution and the combination of the starting mixture. The effect of the acetic acid anion is to increase the driving force for the generation of DCPD crystal nuclei.

Original languageEnglish
Title of host publicationBioceramics 24
PublisherTrans Tech Publications Ltd
Number of pages6
ISBN (Print)9783037855171
Publication statusPublished - 2013
Event24th Symposium and Annual Meeting of International Society for Ceramics in Medicine, ISCM 2012 - Fukuoka, Japan
Duration: 2012 Oct 212012 Oct 24

Publication series

NameKey Engineering Materials
ISSN (Print)1013-9826
ISSN (Electronic)1662-9795


Conference24th Symposium and Annual Meeting of International Society for Ceramics in Medicine, ISCM 2012


  • Brushite
  • DCPD
  • Morphology
  • Solution-phase synthesis


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