TY - JOUR
T1 - Effect of apigenin on surface-associated characteristics and adherence of streptococcus mutans
AU - Liu, Yinchen
AU - Han, Lin
AU - Yang, Hongye
AU - Liu, Siying
AU - Huang, Cui
N1 - Funding Information:
This work was supported by the National Natural Science Foundation of China (81371191, 81600894), and the Natural Science Foundation of Hubei Province (2017CFB798). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.
Publisher Copyright:
© 2020, Japanese Society for Dental Materials and Devices. All rights reserved.
PY - 2020
Y1 - 2020
N2 - Apigenin is a type of flavonols that exhibits anti-caries properties. Bacterial adherence is the initial step in the forming of a stable biofilm that leads to caries. Bacterial adherence is affected by surface characteristics, including hydrophobicity and bacterial aggregation. However, the effect of apigenin on surface characteristics of cariogenic bacteria has not been reported. We aimed to examine the effects of apigenin on adherence and biofilm formation of Streptococcus mutans UA159. Hydrophobicity and bacterial aggregation, pac and gbpC gene expressions, and cytotoxicity on human dental pulp cells were also determined. Apigenin significantly inhibited the adherence and biofilm formation of S. mutans. Hydrophobicity decreased, whereas the aggregation rate was significantly increased compared with the control. Apigenin significantly suppressed pac and gbpC gene expressions. Apigenin exhibited acceptable biocompatibility on hDPCs. Thus, apigeinin may affect adherence and biofilm formation by altering the surface properties of S. mutans without obvious adverse effect on hDPCs.
AB - Apigenin is a type of flavonols that exhibits anti-caries properties. Bacterial adherence is the initial step in the forming of a stable biofilm that leads to caries. Bacterial adherence is affected by surface characteristics, including hydrophobicity and bacterial aggregation. However, the effect of apigenin on surface characteristics of cariogenic bacteria has not been reported. We aimed to examine the effects of apigenin on adherence and biofilm formation of Streptococcus mutans UA159. Hydrophobicity and bacterial aggregation, pac and gbpC gene expressions, and cytotoxicity on human dental pulp cells were also determined. Apigenin significantly inhibited the adherence and biofilm formation of S. mutans. Hydrophobicity decreased, whereas the aggregation rate was significantly increased compared with the control. Apigenin significantly suppressed pac and gbpC gene expressions. Apigenin exhibited acceptable biocompatibility on hDPCs. Thus, apigeinin may affect adherence and biofilm formation by altering the surface properties of S. mutans without obvious adverse effect on hDPCs.
KW - Apigenin
KW - Bacterial aggregation
KW - Hydrophobicity
KW - Streptococcus mutans
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U2 - 10.4012/dmj.2019-255
DO - 10.4012/dmj.2019-255
M3 - Article
C2 - 33028784
AN - SCOPUS:85097210808
SN - 0287-4547
VL - 39
SP - 933
EP - 940
JO - Dental Materials Journal
JF - Dental Materials Journal
IS - 6
ER -