This study aimed to evaluate the effect of the configuration of implants supporting a four-unit fixed partial denture on load distribution. An epoxy resin model missing teeth from the first premolar to the second molar was used. Three-dimensional piezoelectric force transducers were set on implants placed in the missing teeth area with a four-unit experimental superstructure. Three-dimensional loads on the implants were measured with four different implant configurations when a static load of 100 N was applied. The loads on the implants changed significantly depending on the implant number and position and the applied loading points.