Abstract
CpG oligonucleotides stimulate via TLR9 and enhance anti-tumor immunity, an effect attributed to the activation of NK and CD8+ T cells. Our recent work demonstrates that CpG ODN also induce monocytic myeloid-derived suppressor cells to mature into M1 macrophages, further aiding tumor elimination. This provides insight into the mechanism through which CpG promote tumor regression.
| Original language | English |
|---|---|
| Pages (from-to) | 780-782 |
| Number of pages | 3 |
| Journal | OncoImmunology |
| Volume | 1 |
| Issue number | 5 |
| DOIs | |
| Publication status | Published - 2012 |
Keywords
- CpG ODN
- CpG oligonucleotides
- Immunotherapy
- Myeloid derived suppressor cells
- Myeloid-derived suppressor cells
- TLR9
- Toll like receptor
- Tumor microenvironment
- Tumor-associated macrophages