Effect of enhanced recovery after surgery protocol on recovery after open hepatectomy: A randomized clinical trial

Wataru Nakanishi, Shigehito Miyagi, Kazuaki Tokodai, Atsushi Fujio, Kengo Sasaki, Yoshihiro Shono, Michiaki Unno, Takashi Kamei

Research output: Contribution to journalArticlepeer-review

4 Citations (Scopus)


Purpose: Enhanced recovery after surgery (ERAS) is beneficial to patients undergoing digestive surgery. However, its efficacy in patients undergoing open hepatectomy remains unclear. Methods: Consecutive patients scheduled for open hepatectomy were randomly assigned to undergo either ERAS or conventional postoperative management. The primary endpoint was the amount of time that elapsed before patients were considered medically fit for discharge (MFD) and length of hospital stay (LOHS). Secondary endpoints included morbidity, mortality, the time to first flatus, defecation, first walk, and freedom from infusion. Perioperative serum nutritional markers, insulin resistance, respiratory quotient (RQ), and resting energy expenditure (REE) were also assessed. Results: Between August 2014 and March 2017, 57 patients were randomized into 2 groups; ERAS group (n = 29) and conventional management (n = 28). The median MFD was not significantly different between the ERAS and conventional management groups (6.5 vs. 7 days; P = 0.381). Recovery from gastrointestinal paresis was significantly quicker in the ERAS group (1.8 vs. 2.4 days; P = 0.004). There were no significant differences in serum markers, insulin resistance, RQ, and REE. Conclusion: This trial did not demonstrate greater efficacy of the ERAS protocol following open hepatectomy in terms of the MFD and LOHS. However, the ERAS protocol was associated with better recovery from postoperative gastrointestinal paresis, suggesting that it is useful for patients undergoing open hepatectomy.

Original languageEnglish
Pages (from-to)320-328
Number of pages9
JournalAnnals of Surgical Treatment and Research
Issue number6
Publication statusPublished - 2020 Dec


  • Enhanced recovery after surgery
  • Hepatectomy
  • Perioperative treatments
  • Randomized controlled trial


Dive into the research topics of 'Effect of enhanced recovery after surgery protocol on recovery after open hepatectomy: A randomized clinical trial'. Together they form a unique fingerprint.

Cite this