Effect of leftventricular assistance for transient myocardial ischemia and recovery period

Y. Kakinuma, T. Yambe, T. Sonobe, S. Naganuma, H. Akiho, K. Idutsu, S. Kobayashi, S. Nanka, S. Nitta, N. Uchida, T. Fukuju, M. Miura, K. Tabayashi, M. Yoshizawa

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In order to analyze the effect of left ventricular assist (LV-assist) on the stunned myocardium, acute animal experiments using 4 adult goats were carried out using the model of transient ischemia occluding the left anterior descending coronary artery for 3 minites. In this study, the end-systolic point (ESP) and the end-diastolic point (EDP) were calculated using pressure- volume curve (P-V curve) during transient ischemia and the recovery period, with and without LV-assist. In all parameters of ESP and EDP, LV-assist decreased the recovery time from transient myocardial ischemia. These results suggest that the decrease in pre-load and after-load with LV-assist contributes to the early recovery from stunned myocardium.

Original languageEnglish
Pages (from-to)18-24
Number of pages7
JournalJapanese Journal of Artificial Organs
Issue number1
Publication statusPublished - 1996


  • P-V curve
  • end-diastolic point
  • end-systolic point
  • left ventricular assist
  • transient ischemia


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