Effect of obstructive jaundice on acute gastric ulceration viewed from gastric mucosal energy metabolism in rats

The mechanism of acute gastric ulceration in rats with obstructive jaundice was investigated in terms of the changes in the gastric mucosal energy metabolism. Rats were divided into 4 groups as follows: control, vagotomized, jaundiced, and jaundiced and vagotomized group. The water immersion and restraint procedures were performed and the ulcer index was calculated. The change of energy metabolism in the gastric mucosa of corpus and antrum was clarified by measuring ATP and energy charge. The following results were obtained: Vagotomized group showed significant decreased ulcer index, however, the gastric mucosal energy metabolism were unchanged compared to the control group after stress. Jaundiced group showed significant higher ulcer index, and the early, significant depression of the gastric mucosal energy metabolism compared to the control group. Jaundiced and vagotomized group showed significant improvement of ulcer index and gastric mucosal energy metabolism compared to the jaundiced group. The gastric energy metabolism of the corpus revealed more prominent depression than that of the antrum in jaundiced group, and jaundiced and vagotomized group. These data suggested that the deterioration of the gastric mucosal energy metabolism after stress was enhanced under the condition of obstructive jaundice and these results were improved by vagotomy.