Effect of polyols on phosphorus-containing calcium fluoride deposition on hydroxyapatite surfaces

Sei Tsutsui; Takahisa Anada; Yukari Shiwaku; Atsushi Yamagishi; Osamu Suzuki

doi:10.2485/jhtb.27.34

Effect of polyols on phosphorus-containing calcium fluoride deposition on hydroxyapatite surfaces

Sei Tsutsui, Takahisa Anada, Yukari Shiwaku, Atsushi Yamagishi, Osamu Suzuki

DEN - Dental Sciences

Research output: Contribution to journal › Article › peer-review

1 Citation (Scopus)

Abstract

The present study investigated how polyols (sugar alcohols) affect the formation of calcium fluoride (CaF₂) in the presence of fluoride on synthetic hydroxyapatite (HA) as a model of tooth enamel. HA plates were immersed in sugar alcohol solutions containing 10-60 (w/w)% xylitol, D-sorbitol, or glycerol and 1000 ppm fluoride at room temperature to analyze CaF₂ formation on the surfaces. Only glycerol enhanced fluoride incorporation significantly and induced a nanoscale spherical deposition on the HA surface composed of calcium, fluoride, and a small amount of phosphorous according to energy-dispersive X-ray spectroscopic analysis. Overall results suggest that glycerol is capable of dissolving HA surfaces and enhancing phosphorous-containing CaF₂ deposition, which can potentially prevent dental caries through the enhanced remineralization of enamel surfaces. Thus, fluoride may be involved in controlling the entire process of CaF₂ deposition, dissolution, and remineralization of enamel.

Original language	English
Pages (from-to)	34-38
Number of pages	5
Journal	Journal of Hard Tissue Biology
Volume	27
Issue number	1
DOIs	https://doi.org/10.2485/jhtb.27.34
Publication status	Published - 2018

Keywords

Calcium fluoride
Enamel
Fluoride
Hydroxyapatite
Polyols

ASJC Scopus subject areas

Medicine (miscellaneous)
Biochemistry
Biomaterials
Orthopedics and Sports Medicine
Dentistry(all)
Cell Biology

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title = "Effect of polyols on phosphorus-containing calcium fluoride deposition on hydroxyapatite surfaces",

abstract = "The present study investigated how polyols (sugar alcohols) affect the formation of calcium fluoride (CaF2) in the presence of fluoride on synthetic hydroxyapatite (HA) as a model of tooth enamel. HA plates were immersed in sugar alcohol solutions containing 10-60 (w/w)% xylitol, D-sorbitol, or glycerol and 1000 ppm fluoride at room temperature to analyze CaF2 formation on the surfaces. Only glycerol enhanced fluoride incorporation significantly and induced a nanoscale spherical deposition on the HA surface composed of calcium, fluoride, and a small amount of phosphorous according to energy-dispersive X-ray spectroscopic analysis. Overall results suggest that glycerol is capable of dissolving HA surfaces and enhancing phosphorous-containing CaF2 deposition, which can potentially prevent dental caries through the enhanced remineralization of enamel surfaces. Thus, fluoride may be involved in controlling the entire process of CaF2 deposition, dissolution, and remineralization of enamel.",

keywords = "Calcium fluoride, Enamel, Fluoride, Hydroxyapatite, Polyols",

author = "Sei Tsutsui and Takahisa Anada and Yukari Shiwaku and Atsushi Yamagishi and Osamu Suzuki",

note = "Funding Information: This study was supported in part by Grants-In-Aid (15K15720) from the Ministry of Education, Science, Sports, and Culture of Japan. We are grateful to Drs. Yoshitaka Yano (Kao Corp., Tokyo, Japan) and Hajime Yamazaki (Forsyth Institute, Cambridge, MA, USA) for their critical and essential advice in planning the study from the viewpoint of biomineralization. Focused ion beam-STEM and EDS measurements were supported by Melco Semiconductor Engineering Corp., Fukuoka, Japan. Publisher Copyright: {\textcopyright} 2018 The Hard Tissue Biology Network Association Printed in Japan, All rights reserved.",

year = "2018",

doi = "10.2485/jhtb.27.34",

language = "English",

volume = "27",

pages = "34--38",

journal = "Journal of Hard Tissue Biology",

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AU - Tsutsui, Sei

AU - Anada, Takahisa

AU - Shiwaku, Yukari

AU - Yamagishi, Atsushi

AU - Suzuki, Osamu

N1 - Funding Information: This study was supported in part by Grants-In-Aid (15K15720) from the Ministry of Education, Science, Sports, and Culture of Japan. We are grateful to Drs. Yoshitaka Yano (Kao Corp., Tokyo, Japan) and Hajime Yamazaki (Forsyth Institute, Cambridge, MA, USA) for their critical and essential advice in planning the study from the viewpoint of biomineralization. Focused ion beam-STEM and EDS measurements were supported by Melco Semiconductor Engineering Corp., Fukuoka, Japan. Publisher Copyright: © 2018 The Hard Tissue Biology Network Association Printed in Japan, All rights reserved.

PY - 2018

Y1 - 2018

N2 - The present study investigated how polyols (sugar alcohols) affect the formation of calcium fluoride (CaF2) in the presence of fluoride on synthetic hydroxyapatite (HA) as a model of tooth enamel. HA plates were immersed in sugar alcohol solutions containing 10-60 (w/w)% xylitol, D-sorbitol, or glycerol and 1000 ppm fluoride at room temperature to analyze CaF2 formation on the surfaces. Only glycerol enhanced fluoride incorporation significantly and induced a nanoscale spherical deposition on the HA surface composed of calcium, fluoride, and a small amount of phosphorous according to energy-dispersive X-ray spectroscopic analysis. Overall results suggest that glycerol is capable of dissolving HA surfaces and enhancing phosphorous-containing CaF2 deposition, which can potentially prevent dental caries through the enhanced remineralization of enamel surfaces. Thus, fluoride may be involved in controlling the entire process of CaF2 deposition, dissolution, and remineralization of enamel.

AB - The present study investigated how polyols (sugar alcohols) affect the formation of calcium fluoride (CaF2) in the presence of fluoride on synthetic hydroxyapatite (HA) as a model of tooth enamel. HA plates were immersed in sugar alcohol solutions containing 10-60 (w/w)% xylitol, D-sorbitol, or glycerol and 1000 ppm fluoride at room temperature to analyze CaF2 formation on the surfaces. Only glycerol enhanced fluoride incorporation significantly and induced a nanoscale spherical deposition on the HA surface composed of calcium, fluoride, and a small amount of phosphorous according to energy-dispersive X-ray spectroscopic analysis. Overall results suggest that glycerol is capable of dissolving HA surfaces and enhancing phosphorous-containing CaF2 deposition, which can potentially prevent dental caries through the enhanced remineralization of enamel surfaces. Thus, fluoride may be involved in controlling the entire process of CaF2 deposition, dissolution, and remineralization of enamel.

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KW - Polyols

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Effect of polyols on phosphorus-containing calcium fluoride deposition on hydroxyapatite surfaces

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