Effect of rice-expressed amyloid β in the Tg2576 Alzheimer's disease transgenic mouse model

Jun Nojima, Azusa Maeda, Sho Aoki, Satoshi Suo, Dai Yanagihara, Yuichiro Watanabe, Taiji Yoshida, Shoichi Ishiura

Research output: Contribution to journalArticlepeer-review

19 Citations (Scopus)

Abstract

One of the main hallmarks of Alzheimer's disease (AD) is senile plaques composed of amyloid β (Aβ). We developed a new edible vaccine: rice expressing GFP-Aβ42. In a previous report, we described the production of anti-Aβ antibodies in B6 mice fed Aβ rice mixed with cholera toxin B subunit (CTB). In this report, we investigated whether Aβ rice had therapeutic effects in the Tg2576 AD model mice. The anti-Aβ antibody titer was increased and levels of intracerebral Aβ (soluble and insoluble) and serum Aβ decreased. Because the value of IgG1/IgG2a in the Aβ feeding group was >1, immunization via Aβ rice may induce a non-inflammatory Th2 reaction. We also found that the Aβ vaccine improved memory, as assessed in a Y-maze test. The number of arm entries in the Y-maze test was lower in the Aβ feeding group than in the control group. These results suggest that the new edible vaccine Aβ rice may have therapeutic effects in AD.

Original languageEnglish
Pages (from-to)6252-6258
Number of pages7
JournalVaccine
Volume29
Issue number37
DOIs
Publication statusPublished - 2011 Aug 26

Keywords

  • Alzheimer's disease
  • Oral vaccination
  • Rice vaccine
  • Tg2576 mice

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