TY - GEN
T1 - Effect of silicate incorporation in alpha-tricalcium phosphate on behaviors of osteoblast-like cells
AU - Kamitakahara, Masanobu
AU - Shirato, Takashi
AU - Yokoi, Taishi
AU - Matsubara, Hideaki
AU - Shibata, Yasuaki
AU - Ikeda, Tohru
N1 - Publisher Copyright:
© 2017 Trans Tech Publications.
Copyright:
Copyright 2020 Elsevier B.V., All rights reserved.
PY - 2017
Y1 - 2017
N2 - Silicate-containing alpha-tricalcium phosphate (α-TCP) ceramics are expected to be useful scaffolds for bone regeneration because α-TCP shows high biodegradability and silicate ions are expected to promote the bone formation. We previously revealed that the porous silicate-containing α-TCP granules provided earlier bone formation and showed lower biodegradability than the porous silicate-free α-TCP granules in vivo. In order to reveal the mechanism of the bone formation promoted by silicate incorporation, the proliferation and differentiation of osteoblast-like cells on the silicate-containing and silicate-free α-TCP ceramics were examined in vitro. The silicate incorporation in α-TCP promoted the differentiation of osteoblast-like cells, and it might be one of the factors to promote bone formation in vivo.
AB - Silicate-containing alpha-tricalcium phosphate (α-TCP) ceramics are expected to be useful scaffolds for bone regeneration because α-TCP shows high biodegradability and silicate ions are expected to promote the bone formation. We previously revealed that the porous silicate-containing α-TCP granules provided earlier bone formation and showed lower biodegradability than the porous silicate-free α-TCP granules in vivo. In order to reveal the mechanism of the bone formation promoted by silicate incorporation, the proliferation and differentiation of osteoblast-like cells on the silicate-containing and silicate-free α-TCP ceramics were examined in vitro. The silicate incorporation in α-TCP promoted the differentiation of osteoblast-like cells, and it might be one of the factors to promote bone formation in vivo.
KW - Alpha-tricalcium phosphate
KW - Osteoblast
KW - Silicate
UR - http://www.scopus.com/inward/record.url?scp=85000948488&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85000948488&partnerID=8YFLogxK
U2 - 10.4028/www.scientific.net/KEM.720.90
DO - 10.4028/www.scientific.net/KEM.720.90
M3 - Conference contribution
AN - SCOPUS:85000948488
SN - 9783038357568
T3 - Key Engineering Materials
SP - 90
EP - 94
BT - Multifunctional Bioceramics for Innovative Therapy
A2 - El-Ghannam, Ahmed
PB - Trans Tech Publications Ltd
T2 - 28th Annual Meeting of the International Society for Ceramics in Medicine, Bioceramics 2016
Y2 - 18 October 2016 through 21 October 2016
ER -