TY - JOUR
T1 - Effect of surrounding chemical environment on adsorption and accumulation of serum protein onto octacalcium phosphate crystals
AU - Hamai, Ryo
AU - Tsuchiya, Kaori
AU - Suzuki, Osamu
N1 - Publisher Copyright:
© 2020 Japan Society of Powder and Powder Metallurgy.
PY - 2020
Y1 - 2020
N2 - Octacalcium phosphate (OCP; Ca8(HPO4)2(PO4)4·5H2O) is a precursor of hydroxyapatite (HA; Ca10(PO4)6(OH)2). OCP is allowed to convert into HA (Ca-deficient HA) through a hydrolysis reaction in vivo and in vitro, because OCP and HA are metastable and stable phase under the physiological condition, respectively. Dissolution-reprecipitation reaction and ion diffusion-crystallization in hydrated layer are considered the mechanisms of the hydrolysis reaction. We have reported that chemical environment regulated by the hydrolysis of OCP stimulates osteoblastic and osteoclastic differentiation resulting in showing higher osteoconductivity and biodegradability of this material in various animal bone defect models. Based on these results, the possibility applying OCP as a bone substitute has been examined. Adsorption of serum proteins also controls the activities of the cells on the surface of biomaterials. Previous in vivo and in vitro studies indicate that accumulation of serum proteins onto OCP surface is involved in the bone formation by osteoblasts. However, it is still unclear about how surrounding chemical environment regulated by the OCP afects the behavior of serum protein adsorption onto OCP crystals. In this review article, the bioactivities of OCP related with its physiochemical properties including the protein adsorption will be explained.
AB - Octacalcium phosphate (OCP; Ca8(HPO4)2(PO4)4·5H2O) is a precursor of hydroxyapatite (HA; Ca10(PO4)6(OH)2). OCP is allowed to convert into HA (Ca-deficient HA) through a hydrolysis reaction in vivo and in vitro, because OCP and HA are metastable and stable phase under the physiological condition, respectively. Dissolution-reprecipitation reaction and ion diffusion-crystallization in hydrated layer are considered the mechanisms of the hydrolysis reaction. We have reported that chemical environment regulated by the hydrolysis of OCP stimulates osteoblastic and osteoclastic differentiation resulting in showing higher osteoconductivity and biodegradability of this material in various animal bone defect models. Based on these results, the possibility applying OCP as a bone substitute has been examined. Adsorption of serum proteins also controls the activities of the cells on the surface of biomaterials. Previous in vivo and in vitro studies indicate that accumulation of serum proteins onto OCP surface is involved in the bone formation by osteoblasts. However, it is still unclear about how surrounding chemical environment regulated by the OCP afects the behavior of serum protein adsorption onto OCP crystals. In this review article, the bioactivities of OCP related with its physiochemical properties including the protein adsorption will be explained.
KW - Biodegradability
KW - Octacalcium phosphate
KW - Osteoconductivity
KW - Serum protein adsorption
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U2 - 10.2497/jjspm.67.258
DO - 10.2497/jjspm.67.258
M3 - Review article
AN - SCOPUS:85086239358
SN - 0532-8799
VL - 67
SP - 258
EP - 263
JO - Funtai Oyobi Fummatsu Yakin/Journal of the Japan Society of Powder and Powder Metallurgy
JF - Funtai Oyobi Fummatsu Yakin/Journal of the Japan Society of Powder and Powder Metallurgy
IS - 5
ER -