TY - JOUR
T1 - Effect of Various Exercises on Intrinsic Capacity in Older Adults With Subjective Cognitive Concerns
AU - Huang, Chi Hsien
AU - Umegaki, Hiroyuki
AU - Makino, Taeko
AU - Uemura, Kazuki
AU - Hayashi, Takahiro
AU - Kitada, Tomoharu
AU - Inoue, Aiko
AU - Shimada, Hiroyuki
AU - Kuzuya, Masafumi
N1 - Funding Information:
This work received financial support from grants from the Center of Innovation Program (COI STREAM), the Ministry of Education, Culture, Sports, Science and Technology (MEXT) (No. 65-Z25–0160 ), and the Japan Science and Technology Agency (JST) (No. 65-J-J0033 ). The funding body had no roles in the study design, data collection, data analysis, and interpretation, or the report writing.
Publisher Copyright:
© 2020 AMDA – The Society for Post-Acute and Long-Term Care Medicine
PY - 2021/4
Y1 - 2021/4
N2 - Objectives: Physical activity is associated with improvement in overall health and well-being, but robust evidence with comprehensive assessment of general health is lacking. This study aimed to clarify the effects of physical activity on intrinsic capacity among community-dwelling older adults with subjective memory concerns. Design: A single-blind randomized controlled trial compared aerobic training (AT), resistance training (RT), and combined training (AT+RT) programs for improving general health evaluated by intrinsic capacity. Setting: Toyota, Japan. Participants: Residents (65–85 years old) who screened positive for subjective memory concerns using the Kihon checklist were invited for eligibility assessment. In total, 415 community-dwelling older adults were enrolled and randomized into the AT, RT, AT+RT, and control groups. Methods: Participants in the intervention groups underwent a group training program and self-paced home training for 26 weeks. The control group received lectures about health promotion. Intrinsic capacity (IC), constructed based on locomotion, cognition, psychological function, and vitality domains, was used to assess general health at baseline, week 26, and week 52. Between-group differences were exhibited with Z-score change in individual domain and combination of all domains. Results: At baseline, mean age of all participants (47% women) was 72.3 ± 4.6 years, with a mean composited IC Z-score of −0.2 ± 0.5. Overall, AT and RT improved composite IC Z-scores by 0.17 (95% confidence interval [CI] 0.03–0.30) and 0.17 (95% CI 0.05–0.28) at week 26, respectively, but the beneficial effects waned at week 52. No significant differences in composite IC Z-scores were found in the AT+RT group at weeks 26 and 52. Conclusions and Implications: Twenty-six-week AT with self-paced home training and RT with self-paced home training improve IC among community-dwelling older adults with subjective memory concerns, but the benefits waned subsequently. It will be required to develop optimal interventions that have a continuous beneficial effect on IC among community-dwelling older adults.
AB - Objectives: Physical activity is associated with improvement in overall health and well-being, but robust evidence with comprehensive assessment of general health is lacking. This study aimed to clarify the effects of physical activity on intrinsic capacity among community-dwelling older adults with subjective memory concerns. Design: A single-blind randomized controlled trial compared aerobic training (AT), resistance training (RT), and combined training (AT+RT) programs for improving general health evaluated by intrinsic capacity. Setting: Toyota, Japan. Participants: Residents (65–85 years old) who screened positive for subjective memory concerns using the Kihon checklist were invited for eligibility assessment. In total, 415 community-dwelling older adults were enrolled and randomized into the AT, RT, AT+RT, and control groups. Methods: Participants in the intervention groups underwent a group training program and self-paced home training for 26 weeks. The control group received lectures about health promotion. Intrinsic capacity (IC), constructed based on locomotion, cognition, psychological function, and vitality domains, was used to assess general health at baseline, week 26, and week 52. Between-group differences were exhibited with Z-score change in individual domain and combination of all domains. Results: At baseline, mean age of all participants (47% women) was 72.3 ± 4.6 years, with a mean composited IC Z-score of −0.2 ± 0.5. Overall, AT and RT improved composite IC Z-scores by 0.17 (95% confidence interval [CI] 0.03–0.30) and 0.17 (95% CI 0.05–0.28) at week 26, respectively, but the beneficial effects waned at week 52. No significant differences in composite IC Z-scores were found in the AT+RT group at weeks 26 and 52. Conclusions and Implications: Twenty-six-week AT with self-paced home training and RT with self-paced home training improve IC among community-dwelling older adults with subjective memory concerns, but the benefits waned subsequently. It will be required to develop optimal interventions that have a continuous beneficial effect on IC among community-dwelling older adults.
KW - cognition
KW - exercise
KW - healthy aging
KW - Intrinsic capacity
KW - physical training
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U2 - 10.1016/j.jamda.2020.06.048
DO - 10.1016/j.jamda.2020.06.048
M3 - Article
C2 - 32768376
AN - SCOPUS:85089103679
SN - 1525-8610
VL - 22
SP - 780-786.e2
JO - Journal of the American Medical Directors Association
JF - Journal of the American Medical Directors Association
IS - 4
ER -
