The calculation by the semi-empirical molecular orbital method concerning the effect of zinc halides on the high stereoselectivity of a new Mannich type cyclization in our tilivalline synthesis has revealed that (1) zinc chloride coordinates with the N10 atom during the reaction and (2) the steric hindrance on the α side and the extension of LUMO to the β side in the intermediate 7 govern the high steroselectivity.
|Number of pages||6|
|Publication status||Published - 1994|
ASJC Scopus subject areas
- Drug Discovery
- Organic Chemistry