Effectiveness of dmso intravesical therapy for lower urinary symptoms of primary amyloidosis localized in the urinary bladder: A case report

Primary amyloidosis localized in the urinary bladder is comparatively rare, and 40% of the patients complain of lower urinary tract symptoms (LUTS). Although standard management for amyloidosis localized in the urinary bladder is not established, transurethral resection (TUR) is performed in most of the cases to diagnose the disease and to control bleeding. TUR is not considered as radical therapy for amyloidosis localized in the urinary bladder because of frequent recurrence. Dimethyl sulfoxide (DMSO) administered through intravenous, percutaneous or intravesical route has been shown to be effective for treating and preventing recurrence of the disease, but its effect on LUTS due to amyloidosis localized in the urinary bladder has not been demonstrated. We report a case showing improvement of LUTS and in which recurrence of amyloidosis localized in the urinary bladder was prevented for 18 months by intravesical DMSO therapy.