TY - JOUR
T1 - Effects and Mechanisms of Tastants on the Gustatory-Salivary Reflex in Human Minor Salivary Glands
AU - Satoh-Kuriwada, Shizuko
AU - Shoji, Noriaki
AU - Miyake, Hiroyuki
AU - Watanabe, Chiyo
AU - Sasano, Takashi
N1 - Funding Information:
The authors greatly appreciate the participation of all individuals in this study. This study was supported in part by Grants-in-Aid for Developmental Scientific Research from the Ministry of Education, Science and Culture of Japan (nos. 22590575 and 24590780 to S. Satoh-Kuriwada) and was funded in part by the Ajinomoto Company (Kanagawa, Japan). Finally, the authors thank Angela Morben, DVM, ELS, from Edanz Group for editing a draft of this manuscript.
Publisher Copyright:
© 2018 Shizuko Satoh-Kuriwada et al.
PY - 2018
Y1 - 2018
N2 - The effects and mechanisms of tastes on labial minor salivary gland (LMSG) secretion were investigated in 59 healthy individuals. Stimulation with each of the five basic tastes (i.e., sweet, salty, sour, bitter, and umami) onto the tongue induced LMSG secretion in a dose-dependent manner. Umami and sour tastes evoked greater secretion than did the other tastes. A synergistic effect of umami on LMSG secretion was recognized: A much greater increase in secretion was observed by a mixed solution of monosodium glutamate and inosine 5′-monophosphate than by each separate stimulation. Blood flow (BF) in the nearby labial mucosa also increased following stimulation by each taste except bitter. The BF change and LMSG secretion in each participant showed a significant positive correlation with all tastes, including bitter. Administration of cevimeline hydrochloride hydrate to the labial mucosa evoked a significant increase in both LMSG secretion and BF, while adrenaline, atropine, and pirenzepine decreased LMSG secretion and BF. The change in LMSG secretion and BF induced by each autonomic agent was significantly correlated in each participant. These results indicate that basic tastes can induce the gustatory-salivary reflex in human LMSGs and that parasympathetic regulation is involved in this mechanism.
AB - The effects and mechanisms of tastes on labial minor salivary gland (LMSG) secretion were investigated in 59 healthy individuals. Stimulation with each of the five basic tastes (i.e., sweet, salty, sour, bitter, and umami) onto the tongue induced LMSG secretion in a dose-dependent manner. Umami and sour tastes evoked greater secretion than did the other tastes. A synergistic effect of umami on LMSG secretion was recognized: A much greater increase in secretion was observed by a mixed solution of monosodium glutamate and inosine 5′-monophosphate than by each separate stimulation. Blood flow (BF) in the nearby labial mucosa also increased following stimulation by each taste except bitter. The BF change and LMSG secretion in each participant showed a significant positive correlation with all tastes, including bitter. Administration of cevimeline hydrochloride hydrate to the labial mucosa evoked a significant increase in both LMSG secretion and BF, while adrenaline, atropine, and pirenzepine decreased LMSG secretion and BF. The change in LMSG secretion and BF induced by each autonomic agent was significantly correlated in each participant. These results indicate that basic tastes can induce the gustatory-salivary reflex in human LMSGs and that parasympathetic regulation is involved in this mechanism.
UR - http://www.scopus.com/inward/record.url?scp=85042103636&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85042103636&partnerID=8YFLogxK
U2 - 10.1155/2018/3847075
DO - 10.1155/2018/3847075
M3 - Article
C2 - 29651428
AN - SCOPUS:85042103636
SN - 2314-6133
VL - 2018
JO - BioMed Research International
JF - BioMed Research International
M1 - 3847075
ER -
