Effects of combination chemoradiotherapy with daily low-dose CDDP for esophageal cancer - Results of a randomized trial

T. Kaneta; Y. Takai; K. Nemoto; Y. Kakuto; Y. Ogawa; H. Ariga; S. Maruoka; Tadashi Ishibashi; Y. Hosoi; S. Yamada

Effects of combination chemoradiotherapy with daily low-dose CDDP for esophageal cancer - Results of a randomized trial

T. Kaneta, Y. Takai, K. Nemoto, Y. Kakuto, Y. Ogawa, H. Ariga, S. Maruoka, Tadashi Ishibashi, Y. Hosoi, S. Yamada

Research output: Contribution to journal › Article › peer-review

Abstract

Between 1994 and 1996, 24 patients with esophageal carcinoma were entered in a randomized clinical trial comparing radiotherapy (RT) only (arm A) versus RT and a daily low dose of CDDP (5mg/m²) (arm B). For arm B group, CDDP was infected within 30 min after irradiation. All patients were irradiated with a total dose of 60 Gy/30fr. at first, and some patients were boosted. An overall response rate of 75.0% (complete response raze of 25.0%) was observed in arm A and 91.7 % (complete response rate of 16.7 %) in arm B, respectively. The survival rate at 1 year was 23.8 % in arm A and 40.0% in arm B. Median survival time was 7 months in arm A and 9 months in arm B. Toxicity was acceptable and no significant difference was noted between arm A and arm B.

Original language	English
Pages (from-to)	2099-2104
Number of pages	6
Journal	Japanese Journal of Cancer and Chemotherapy
Volume	24
Issue number	14
Publication status	Published - 1997

Keywords

CDDP
Esophageal cancer
Radiotherapy

ASJC Scopus subject areas

Medicine(all)

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Cite this

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title = "Effects of combination chemoradiotherapy with daily low-dose CDDP for esophageal cancer - Results of a randomized trial",

abstract = "Between 1994 and 1996, 24 patients with esophageal carcinoma were entered in a randomized clinical trial comparing radiotherapy (RT) only (arm A) versus RT and a daily low dose of CDDP (5mg/m2) (arm B). For arm B group, CDDP was infected within 30 min after irradiation. All patients were irradiated with a total dose of 60 Gy/30fr. at first, and some patients were boosted. An overall response rate of 75.0% (complete response raze of 25.0%) was observed in arm A and 91.7 % (complete response rate of 16.7 %) in arm B, respectively. The survival rate at 1 year was 23.8 % in arm A and 40.0% in arm B. Median survival time was 7 months in arm A and 9 months in arm B. Toxicity was acceptable and no significant difference was noted between arm A and arm B.",

keywords = "CDDP, Esophageal cancer, Radiotherapy",

author = "T. Kaneta and Y. Takai and K. Nemoto and Y. Kakuto and Y. Ogawa and H. Ariga and S. Maruoka and Tadashi Ishibashi and Y. Hosoi and S. Yamada",

year = "1997",

language = "English",

volume = "24",

pages = "2099--2104",

journal = "Japanese Journal of Cancer and Chemotherapy",

issn = "0385-0684",

publisher = "Japanese Journal of Cancer and Chemotherapy Publishers Inc.",

number = "14",

}

TY - JOUR

T1 - Effects of combination chemoradiotherapy with daily low-dose CDDP for esophageal cancer - Results of a randomized trial

AU - Kaneta, T.

AU - Takai, Y.

AU - Nemoto, K.

AU - Kakuto, Y.

AU - Ogawa, Y.

AU - Ariga, H.

AU - Maruoka, S.

AU - Ishibashi, Tadashi

AU - Hosoi, Y.

AU - Yamada, S.

PY - 1997

Y1 - 1997

N2 - Between 1994 and 1996, 24 patients with esophageal carcinoma were entered in a randomized clinical trial comparing radiotherapy (RT) only (arm A) versus RT and a daily low dose of CDDP (5mg/m2) (arm B). For arm B group, CDDP was infected within 30 min after irradiation. All patients were irradiated with a total dose of 60 Gy/30fr. at first, and some patients were boosted. An overall response rate of 75.0% (complete response raze of 25.0%) was observed in arm A and 91.7 % (complete response rate of 16.7 %) in arm B, respectively. The survival rate at 1 year was 23.8 % in arm A and 40.0% in arm B. Median survival time was 7 months in arm A and 9 months in arm B. Toxicity was acceptable and no significant difference was noted between arm A and arm B.

AB - Between 1994 and 1996, 24 patients with esophageal carcinoma were entered in a randomized clinical trial comparing radiotherapy (RT) only (arm A) versus RT and a daily low dose of CDDP (5mg/m2) (arm B). For arm B group, CDDP was infected within 30 min after irradiation. All patients were irradiated with a total dose of 60 Gy/30fr. at first, and some patients were boosted. An overall response rate of 75.0% (complete response raze of 25.0%) was observed in arm A and 91.7 % (complete response rate of 16.7 %) in arm B, respectively. The survival rate at 1 year was 23.8 % in arm A and 40.0% in arm B. Median survival time was 7 months in arm A and 9 months in arm B. Toxicity was acceptable and no significant difference was noted between arm A and arm B.

KW - CDDP

KW - Esophageal cancer

KW - Radiotherapy

UR - http://www.scopus.com/inward/record.url?scp=0031467495&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0031467495&partnerID=8YFLogxK

M3 - Article

C2 - 9388519

AN - SCOPUS:0031467495

SN - 0385-0684

VL - 24

SP - 2099

EP - 2104

JO - Japanese Journal of Cancer and Chemotherapy

JF - Japanese Journal of Cancer and Chemotherapy

IS - 14

ER -

Effects of combination chemoradiotherapy with daily low-dose CDDP for esophageal cancer - Results of a randomized trial

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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