TY - JOUR
T1 - Effects of enriched endogenous omega-3 fatty acids on age-related hearing loss in mice
AU - Honkura, Yohei
AU - Suzuki, Jun
AU - Sakayori, Nobuyuki
AU - Inada, Hitoshi
AU - Kawase, Tetsuaki
AU - Katori, Yukio
AU - Osumi, Noriko
N1 - Funding Information:
This work was supported by Grant-in-Aid for Scientific Research (C) from Ministry of Education, Culture, Sports, Science and Technology Japan (K16K11700, J.S.), Grant-in-Aid for Scientific Research (B) from Ministry of Education, Culture, Sports, Science and Technology Japan (#21300115, N.O.), Grant-in-Aid for Scientific Research on Innovative Areas from Ministry of Education, Culture, Sports, Science and Technology Japan (17H06059, N.S.), Research Grant from the Asahi Glass Foundation (N.O.), Research Fellowship of the Japan Society for the Promotion of Science for Young Scientists from the Japan Science and Technology Agency (N.S.), and Scientific Research Promotion Grant from the Mishima Kaiun Memorial Foundation (N.S.).
Publisher Copyright:
© 2019 The Author(s).
PY - 2019/11/26
Y1 - 2019/11/26
N2 - Objective: Dietary intervention is a practical prevention strategy for age-related hearing loss (AHL). Omega-3 (n-3) polyunsaturated fatty acids (PUFAs) may be effective in prevention of AHL due to their anti-inflammatory and tissue-protective functions. Age-related changes in the hearing function of wild-type and Fat-1 transgenic mice derived from the C57BL/6N strain, which can convert omega-6 PUFAs to n-3 PUFAs and consequently produce enriched endogenous n-3 PUFAs, were investigated to test the efficacy of n-3 PUFAs for AHL prevention. Results: At 2 months, the baseline auditory brainstem response (ABR) thresholds were the same in Fat-1 and wild-type mice at 8-16 kHz but were significantly higher in Fat-1 mice at 4 and 32 kHz. In contrast, the ABR thresholds of Fat-1 mice were significantly lower at 10 months. Moreover, the ABR thresholds of Fat-1 mice at low-middle frequencies were significantly lower at 13 months (12 kHz). Body weights were significantly reduced in Fat-1 mice at 13 months, but not at 2, 10, and 16-17 months. In conclusion, enriched endogenous n-3 PUFAs produced due to the expression of the Fat-1 transgene partially alleviated AHL in male C57BL/6N mice.
AB - Objective: Dietary intervention is a practical prevention strategy for age-related hearing loss (AHL). Omega-3 (n-3) polyunsaturated fatty acids (PUFAs) may be effective in prevention of AHL due to their anti-inflammatory and tissue-protective functions. Age-related changes in the hearing function of wild-type and Fat-1 transgenic mice derived from the C57BL/6N strain, which can convert omega-6 PUFAs to n-3 PUFAs and consequently produce enriched endogenous n-3 PUFAs, were investigated to test the efficacy of n-3 PUFAs for AHL prevention. Results: At 2 months, the baseline auditory brainstem response (ABR) thresholds were the same in Fat-1 and wild-type mice at 8-16 kHz but were significantly higher in Fat-1 mice at 4 and 32 kHz. In contrast, the ABR thresholds of Fat-1 mice were significantly lower at 10 months. Moreover, the ABR thresholds of Fat-1 mice at low-middle frequencies were significantly lower at 13 months (12 kHz). Body weights were significantly reduced in Fat-1 mice at 13 months, but not at 2, 10, and 16-17 months. In conclusion, enriched endogenous n-3 PUFAs produced due to the expression of the Fat-1 transgene partially alleviated AHL in male C57BL/6N mice.
KW - Age-related hearing loss
KW - C57BL/6 mouse
KW - Cochlea
KW - Omega-3 (n-3) fatty acids
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U2 - 10.1186/s13104-019-4809-8
DO - 10.1186/s13104-019-4809-8
M3 - Article
C2 - 31771637
AN - SCOPUS:85075687336
SN - 1756-0500
VL - 12
JO - BMC Research Notes
JF - BMC Research Notes
IS - 1
M1 - 768
ER -