TY - JOUR
T1 - Effects of histamine agents on methamphetamine-induced stereotyped behavior and behavioral sensitization in rats
AU - Ito, C.
AU - Onodera, K.
AU - Watanabe, T.
AU - Sato, M.
N1 - Funding Information:
Acknowledgements The authors are grateful to Dr. J. Kollonitsch, Merck Sharp & Dohme Research, Rahway, N.J., USA for a gift of FMH, and Dr. M.E. Parsons, Smith-Kline Beecham, London, UK for supplying zolantidine. This work was partly supported by Grants in-Aid from the Ministry of Education, Science, Sports and Culture of Japan and the Ministry of Health and Welfare of Japan.
PY - 1997
Y1 - 1997
N2 - In this study, effects of histamine (HA) agents on methamphetamine (METH)-induced stereotyped behavior and behavioral sensitization were examined in rats. Pretreatment with a precursor of HA, L-histidine (750 mg/kg), significantly inhibited the METH (3 mg/kg)-induced stereotyped behavior, whereas pretreatment with an inhibitor of HA synthesis, α-fluoromethylhistidine (FMH) (100 mg/kg), an H1 antagonist pyrilamine (5 mg/kg) or an H2 antagonist zolantidine (5 mg/kg) enhanced it. The inhibitory effect of L-histidine on METH-induced stereotyped behavior was significantly blocked by coadministration of pyrilamine and zolantidine, indicating that the effect is mediated through H1 and H2 receptors. Moreover, chronic treatment with METH (3 mg/kg) significantly enhanced stereotyped behavior at the rechallenge with METH (1 mg/kg). Chronic treatment with L-histidine (750 mg/kg) plus METH inhibited the METH-induced argumentation of stereotyped behavior, while that with FMH (100 mg/kg), pyrilamine (5 mg/kg) or zolantidine (5 mg/kg) potentiated it. These findings suggest that the HA neuron system has an inhibitory role in METH-induced stereotyped behavior and behavioral sensitization.
AB - In this study, effects of histamine (HA) agents on methamphetamine (METH)-induced stereotyped behavior and behavioral sensitization were examined in rats. Pretreatment with a precursor of HA, L-histidine (750 mg/kg), significantly inhibited the METH (3 mg/kg)-induced stereotyped behavior, whereas pretreatment with an inhibitor of HA synthesis, α-fluoromethylhistidine (FMH) (100 mg/kg), an H1 antagonist pyrilamine (5 mg/kg) or an H2 antagonist zolantidine (5 mg/kg) enhanced it. The inhibitory effect of L-histidine on METH-induced stereotyped behavior was significantly blocked by coadministration of pyrilamine and zolantidine, indicating that the effect is mediated through H1 and H2 receptors. Moreover, chronic treatment with METH (3 mg/kg) significantly enhanced stereotyped behavior at the rechallenge with METH (1 mg/kg). Chronic treatment with L-histidine (750 mg/kg) plus METH inhibited the METH-induced argumentation of stereotyped behavior, while that with FMH (100 mg/kg), pyrilamine (5 mg/kg) or zolantidine (5 mg/kg) potentiated it. These findings suggest that the HA neuron system has an inhibitory role in METH-induced stereotyped behavior and behavioral sensitization.
KW - α-fluoromethylhistidine
KW - behavioral sensitization
KW - histamine
KW - L-histidine
KW - methamphetamine
KW - pyrilamine
KW - stereotyped behavior
KW - zolantidine
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U2 - 10.1007/s002130050251
DO - 10.1007/s002130050251
M3 - Article
C2 - 9160852
AN - SCOPUS:0030963525
SN - 0033-3158
VL - 130
SP - 362
EP - 367
JO - Psychopharmacology
JF - Psychopharmacology
IS - 4
ER -