TY - JOUR
T1 - Effects of mycoplasmal pneumonia of swine (MPS) lung lesion-selected Landrace pigs on MPS resistance and immune competence in three-way crossbred pigs
AU - Borjigin, Liushiqi
AU - Shimazu, Tomoyuki
AU - Katayama, Yuki
AU - Watanabe, Kouichi
AU - Kitazawa, Haruki
AU - Roh, Sang Gun
AU - Aso, Hisashi
AU - Katoh, Kazuo
AU - Satoh, Masahiro
AU - Suda, Yoshihito
AU - Sakuma, Akiko
AU - Nakajo, Mituru
AU - Suzuki, Keiichi
PY - 2017/4/1
Y1 - 2017/4/1
N2 - To clarify the genetic influence of mycoplasmal pneumonia of swine (MPS) lesion-selected Landrace (La) on MPS resistance and immune characteristics in three-way crossbred pigs (LaWaDa), the LaWaDa pigs were compared with the non-selected crossbred (LbWbDb) and purebred (La) pigs. The MPS lesion score in the three lines was as follows: La line < LaWaDa line < LbWbDb line, with significant differences among the lines. The proportions of myeloid cells and T cells were lower and higher, respectively, in the LaWaDa pigs compared with those in the other two lines. Messenger RNA (mRNA) expression of interleukin (IL)-6, IL-10, transforming growth factor-β, and interferon-γ in peripheral blood was significantly increased after vaccination in the La and LaWaDa lines. IL-4 mRNA expression in the LaWaDa line was intermediate to the La and LbWbDb lines. Furthermore, principal component analysis for immune traits and MPS lesions was executed to clarify the characteristics of each pig line. These findings suggest that the immune responses in the three pig lines are genetically distinct and that MPS resistance and some immunity characteristics from the La line were transmitted to the three-way crossbred pigs.
AB - To clarify the genetic influence of mycoplasmal pneumonia of swine (MPS) lesion-selected Landrace (La) on MPS resistance and immune characteristics in three-way crossbred pigs (LaWaDa), the LaWaDa pigs were compared with the non-selected crossbred (LbWbDb) and purebred (La) pigs. The MPS lesion score in the three lines was as follows: La line < LaWaDa line < LbWbDb line, with significant differences among the lines. The proportions of myeloid cells and T cells were lower and higher, respectively, in the LaWaDa pigs compared with those in the other two lines. Messenger RNA (mRNA) expression of interleukin (IL)-6, IL-10, transforming growth factor-β, and interferon-γ in peripheral blood was significantly increased after vaccination in the La and LaWaDa lines. IL-4 mRNA expression in the LaWaDa line was intermediate to the La and LbWbDb lines. Furthermore, principal component analysis for immune traits and MPS lesions was executed to clarify the characteristics of each pig line. These findings suggest that the immune responses in the three pig lines are genetically distinct and that MPS resistance and some immunity characteristics from the La line were transmitted to the three-way crossbred pigs.
KW - disease resistance
KW - immunogenic property
KW - mycoplasma pneumonia lesion
KW - three-way crossbred pig
UR - http://www.scopus.com/inward/record.url?scp=84987641796&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84987641796&partnerID=8YFLogxK
U2 - 10.1111/asj.12698
DO - 10.1111/asj.12698
M3 - Article
C2 - 27612216
AN - SCOPUS:84987641796
SN - 1344-3941
VL - 88
SP - 575
EP - 585
JO - Animal Science Journal
JF - Animal Science Journal
IS - 4
ER -
