Effects of post-traumatic growth on the dorsolateral prefrontal cortex after a disaster

Seishu Nakagawa; Motoaki Sugiura; Atsushi Sekiguchi; Yuka Kotozaki; Carlos Makoto Miyauchi; Sugiko Hanawa; Tsuyoshi Araki; Hikaru Takeuchi; Atsushi Sakuma; Yasuyuki Taki; Ryuta Kawashima

doi:10.1038/srep34364

Effects of post-traumatic growth on the dorsolateral prefrontal cortex after a disaster

Seishu Nakagawa, Motoaki Sugiura, Atsushi Sekiguchi, Yuka Kotozaki, Carlos Makoto Miyauchi, Sugiko Hanawa, Tsuyoshi Araki, Hikaru Takeuchi, Atsushi Sakuma, Yasuyuki Taki, Ryuta Kawashima

Research output: Contribution to journal › Article › peer-review

16 Citations (Scopus)

Abstract

The relating to others factor of post-traumatic growth (PTG), which involves mutual help and a strong sense of connection with humanity, is important for young people who are coping with stress. The prefrontal cortex (PFC), especially the dorsolateral PFC (DLPFC), may play an important role in post-traumatic stress disorder (PTSD) with regard to coping and resilience. We hypothesized that the neural correlates of PTG may be responsible for resilience to the correlates of PTSD. Our study tested this hypothesis by examining whether measures of PTG, particularly the measures of relating to others after a disaster, were associated with increased regional grey matter volume (rGMV) in the PFC by assessing individuals who had experienced the East Japan Great Earthquake. We calculated the delta-rGMV by subtracting the rGMV obtained 3 months before the disaster from the rGMV obtained after this disaster using voxel-based morphometry. The magnetic resonance imaging data obtained from 26 subjects (M/F: 21/5; age: 21.2 ± 1.6 yrs.) showed that the total scores on a PTG inventory and the subscore for relating to others at the post-assessment were positively and significantly associated with the delta-rGMV in the right DLPFC. The DLPFC seems to be the main neural correlate of PTG.

Original language	English
Article number	34364
Journal	Scientific reports
Volume	6
DOIs	https://doi.org/10.1038/srep34364
Publication status	Published - 2016 Sept 27
Externally published	Yes

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title = "Effects of post-traumatic growth on the dorsolateral prefrontal cortex after a disaster",

abstract = "The relating to others factor of post-traumatic growth (PTG), which involves mutual help and a strong sense of connection with humanity, is important for young people who are coping with stress. The prefrontal cortex (PFC), especially the dorsolateral PFC (DLPFC), may play an important role in post-traumatic stress disorder (PTSD) with regard to coping and resilience. We hypothesized that the neural correlates of PTG may be responsible for resilience to the correlates of PTSD. Our study tested this hypothesis by examining whether measures of PTG, particularly the measures of relating to others after a disaster, were associated with increased regional grey matter volume (rGMV) in the PFC by assessing individuals who had experienced the East Japan Great Earthquake. We calculated the delta-rGMV by subtracting the rGMV obtained 3 months before the disaster from the rGMV obtained after this disaster using voxel-based morphometry. The magnetic resonance imaging data obtained from 26 subjects (M/F: 21/5; age: 21.2 ± 1.6 yrs.) showed that the total scores on a PTG inventory and the subscore for relating to others at the post-assessment were positively and significantly associated with the delta-rGMV in the right DLPFC. The DLPFC seems to be the main neural correlate of PTG.",

author = "Seishu Nakagawa and Motoaki Sugiura and Atsushi Sekiguchi and Yuka Kotozaki and Miyauchi, {Carlos Makoto} and Sugiko Hanawa and Tsuyoshi Araki and Hikaru Takeuchi and Atsushi Sakuma and Yasuyuki Taki and Ryuta Kawashima",

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doi = "10.1038/srep34364",

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AU - Nakagawa, Seishu

AU - Sugiura, Motoaki

AU - Sekiguchi, Atsushi

AU - Kotozaki, Yuka

AU - Miyauchi, Carlos Makoto

AU - Hanawa, Sugiko

AU - Araki, Tsuyoshi

AU - Takeuchi, Hikaru

AU - Sakuma, Atsushi

AU - Taki, Yasuyuki

AU - Kawashima, Ryuta

PY - 2016/9/27

Y1 - 2016/9/27

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Effects of post-traumatic growth on the dorsolateral prefrontal cortex after a disaster

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