Effects of the acute and chronic restraint stresses on the central histaminergic neuron system of Fischer rat

Chihiro Ito; Haowei Shen; Hiroshi Toyota; Yasuhiko Kubota; Eiko Sakurai; Takehiko Watanabe; Mitsumoto Sato

doi:10.1016/S0304-3940(99)00052-X

Effects of the acute and chronic restraint stresses on the central histaminergic neuron system of Fischer rat

Chihiro Ito, Haowei Shen, Hiroshi Toyota, Yasuhiko Kubota, Eiko Sakurai, Takehiko Watanabe, Mitsumoto Sato

IEHE - Division of Research in Student Support

Tohoku University

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43 Citations (Scopus)

Abstract

The effects of acute and chronic restraint stresses on the brain histamine level and histamine N-methyltransferase activity in Fischer rat brain were studied. The acute restraint stress increased the histamine levels in the diencephalon and nucleus accumbens, and increased the histamine N- methyltransferase activities in the nucleus accumbens and striatum. The chronic restraint stress also increased histamine N-methyltransferase activities in the nucleus accumbens and striatum. These results indicate that the acute and chronic restraint stresses increase the brain histamine turnover, which may partly relate to the vulnerability for stress-induced anxiety and depression.

Original language	English
Pages (from-to)	143-145
Number of pages	3
Journal	Neuroscience Letters
Volume	262
Issue number	2
DOIs	https://doi.org/10.1016/S0304-3940(99)00052-X
Publication status	Published - 1999 Mar 5

Keywords

Fischer rat brain
Histamine
Histamine N-methyltransferase
Restraint stresses
Stress vulnerability

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10.1016/S0304-3940(99)00052-X

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title = "Effects of the acute and chronic restraint stresses on the central histaminergic neuron system of Fischer rat",

abstract = "The effects of acute and chronic restraint stresses on the brain histamine level and histamine N-methyltransferase activity in Fischer rat brain were studied. The acute restraint stress increased the histamine levels in the diencephalon and nucleus accumbens, and increased the histamine N- methyltransferase activities in the nucleus accumbens and striatum. The chronic restraint stress also increased histamine N-methyltransferase activities in the nucleus accumbens and striatum. These results indicate that the acute and chronic restraint stresses increase the brain histamine turnover, which may partly relate to the vulnerability for stress-induced anxiety and depression.",

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note = "Funding Information: This study was partly supported by Grants from the Ministry of Health and Welfare and Grants in-Aid from the Ministry of Education, Science, Sports and Culture of Japan.",

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T1 - Effects of the acute and chronic restraint stresses on the central histaminergic neuron system of Fischer rat

AU - Ito, Chihiro

AU - Shen, Haowei

AU - Toyota, Hiroshi

AU - Kubota, Yasuhiko

AU - Sakurai, Eiko

AU - Watanabe, Takehiko

AU - Sato, Mitsumoto

N1 - Funding Information: This study was partly supported by Grants from the Ministry of Health and Welfare and Grants in-Aid from the Ministry of Education, Science, Sports and Culture of Japan.

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N2 - The effects of acute and chronic restraint stresses on the brain histamine level and histamine N-methyltransferase activity in Fischer rat brain were studied. The acute restraint stress increased the histamine levels in the diencephalon and nucleus accumbens, and increased the histamine N- methyltransferase activities in the nucleus accumbens and striatum. The chronic restraint stress also increased histamine N-methyltransferase activities in the nucleus accumbens and striatum. These results indicate that the acute and chronic restraint stresses increase the brain histamine turnover, which may partly relate to the vulnerability for stress-induced anxiety and depression.

AB - The effects of acute and chronic restraint stresses on the brain histamine level and histamine N-methyltransferase activity in Fischer rat brain were studied. The acute restraint stress increased the histamine levels in the diencephalon and nucleus accumbens, and increased the histamine N- methyltransferase activities in the nucleus accumbens and striatum. The chronic restraint stress also increased histamine N-methyltransferase activities in the nucleus accumbens and striatum. These results indicate that the acute and chronic restraint stresses increase the brain histamine turnover, which may partly relate to the vulnerability for stress-induced anxiety and depression.

KW - Fischer rat brain

KW - Histamine

KW - Histamine N-methyltransferase

KW - Restraint stresses

KW - Stress vulnerability

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Effects of the acute and chronic restraint stresses on the central histaminergic neuron system of Fischer rat

Abstract

Keywords

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