Effects of the small molecule dorsomorphin on intracellular signaling

Tadaaki Kudo; Hiroyasu Kanetaka; Kazutoshi Mizuno; Yasuhiro Ryu; Ye Zhang; Mitsuhiro Kano; Yoshinaka Shimizu; Haruhide Hayashi

doi:10.1007/978-4-431-54070-0_31

Effects of the small molecule dorsomorphin on intracellular signaling

Tadaaki Kudo, Hiroyasu Kanetaka, Kazutoshi Mizuno, Yasuhiro Ryu, Ye Zhang, Mitsuhiro Kano, Yoshinaka Shimizu, Haruhide Hayashi

DEN - Dental Sciences

Research output: Chapter in Book/Report/Conference proceeding › Chapter

2 Citations (Scopus)

Abstract

The small molecule dorsomorphin, also known as compound C, is a cell-permeable pyrazolopyrimidine derivative, which acts as a potent and reversible ATP-competitive inhibitor of AMP-activated protein kinase (AMPK). Recent studies indicated that several molecules with functions in other signaling pathways, including bone morphogenetic protein (BMP) signaling, are novel targets of dorsomorphin. This report focuses on two major targets of dorsomorphin and provides insight into the use of dorsomorphin in the analysis of intracellular signaling.

Original language	English
Title of host publication	Interface Oral Health Science 2011
Publisher	Springer Japan
Pages	131-133
Number of pages	3
ISBN (Electronic)	9784431540700
ISBN (Print)	9784431540694
DOIs	https://doi.org/10.1007/978-4-431-54070-0_31
Publication status	Published - 2012 Jan 1

Keywords

Amp-activated protein kinase (AMPK)
Bone morphogenetic protein (BMP)
Dorsomorphin

ASJC Scopus subject areas

Dentistry(all)

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10.1007/978-4-431-54070-0_31

Cite this

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title = "Effects of the small molecule dorsomorphin on intracellular signaling",

abstract = "The small molecule dorsomorphin, also known as compound C, is a cell-permeable pyrazolopyrimidine derivative, which acts as a potent and reversible ATP-competitive inhibitor of AMP-activated protein kinase (AMPK). Recent studies indicated that several molecules with functions in other signaling pathways, including bone morphogenetic protein (BMP) signaling, are novel targets of dorsomorphin. This report focuses on two major targets of dorsomorphin and provides insight into the use of dorsomorphin in the analysis of intracellular signaling. ",

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T1 - Effects of the small molecule dorsomorphin on intracellular signaling

AU - Kudo, Tadaaki

AU - Kanetaka, Hiroyasu

AU - Mizuno, Kazutoshi

AU - Ryu, Yasuhiro

AU - Zhang, Ye

AU - Kano, Mitsuhiro

AU - Shimizu, Yoshinaka

AU - Hayashi, Haruhide

PY - 2012/1/1

Y1 - 2012/1/1

N2 - The small molecule dorsomorphin, also known as compound C, is a cell-permeable pyrazolopyrimidine derivative, which acts as a potent and reversible ATP-competitive inhibitor of AMP-activated protein kinase (AMPK). Recent studies indicated that several molecules with functions in other signaling pathways, including bone morphogenetic protein (BMP) signaling, are novel targets of dorsomorphin. This report focuses on two major targets of dorsomorphin and provides insight into the use of dorsomorphin in the analysis of intracellular signaling.

AB - The small molecule dorsomorphin, also known as compound C, is a cell-permeable pyrazolopyrimidine derivative, which acts as a potent and reversible ATP-competitive inhibitor of AMP-activated protein kinase (AMPK). Recent studies indicated that several molecules with functions in other signaling pathways, including bone morphogenetic protein (BMP) signaling, are novel targets of dorsomorphin. This report focuses on two major targets of dorsomorphin and provides insight into the use of dorsomorphin in the analysis of intracellular signaling.

KW - Amp-activated protein kinase (AMPK)

KW - Bone morphogenetic protein (BMP)

KW - Dorsomorphin

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DO - 10.1007/978-4-431-54070-0_31

M3 - Chapter

AN - SCOPUS:84956996944

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SP - 131

EP - 133

BT - Interface Oral Health Science 2011

PB - Springer Japan

ER -

Effects of the small molecule dorsomorphin on intracellular signaling

Abstract

Keywords

ASJC Scopus subject areas

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