Effects on asthma and induction of interleukin-8 caused by Asian dust particles collected in western Japan

Masanari Watanabe; Jun Kurai; Katsuyuki Tomita; Hiroyuki Sano; Satoshi Abe; Rumiko Saito; Sayaka Minato; Tadashi Igishi; Naoto Burioka; Takanori Sako; Kazuhito Yasuda; Masaaki Mikami; Shinichi Kurita; Hirokazu Tokuyasu; Yasuto Ueda; Tatsuya Konishi; Akira Yamasaki; Setsuya Aiba; Mitsuo Oshimura; Eiji Shimizu

doi:10.3109/02770903.2014.903965

Effects on asthma and induction of interleukin-8 caused by Asian dust particles collected in western Japan

Masanari Watanabe, Jun Kurai, Katsuyuki Tomita, Hiroyuki Sano, Satoshi Abe, Rumiko Saito, Sayaka Minato, Tadashi Igishi, Naoto Burioka, Takanori Sako, Kazuhito Yasuda, Masaaki Mikami, Shinichi Kurita, Hirokazu Tokuyasu, Yasuto Ueda, Tatsuya Konishi, Akira Yamasaki, Setsuya Aiba, Mitsuo Oshimura, Eiji Shimizu

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18 Citations (Scopus)

Abstract

Objective: Asian dust storms (ADS) contain various airborne particles that may augment airway inflammation by increasing the level of interleukin-8. The objective of the study was to investigate the association of exposure to an ADS with worsening of symptoms of adult asthma and the effect of ADS particles on interleukin-8 transcriptional activity. Methods: The subjects were 112 patients with mild to moderate asthma who recorded scores for their daily upper and lower respiratory tract symptoms and measured morning peak expiratory flow (PEF) from March to May 2011. Interleukin-8 transcriptional activity was assessed in THP-G8 cells that were exposed to airborne particles collected during days of ADS exposure. Results: Of the 112 patients, 31 had comorbid allergic rhinitis (AR) and/or chronic sinusitis (CS), and had worsened scores for upper respiratory tract symptoms on ADS days compared to non-ADS days. Scores for lower respiratory tract symptoms during ADS days were higher than non-ADS days in all patients. Three patients also had unscheduled hospital visits for exacerbation of asthma on ADS days. However, there was no significant difference in daily morning PEF between ADS and non-ADS days. Airborne particles collected on ADS days induced interleukin-8 transcriptional activity in THP-G8 cells compared to the original soil of the ADS. Conclusion: Exposure to an ADS aggravates upper and lower tract respiratory symptoms in patients with adult asthma. ADS airborne particles may increase airway inflammation through enhancement of interleukin-8 transcriptional activity.

Original language	English
Pages (from-to)	595-602
Number of pages	8
Journal	Journal of Asthma
Volume	51
Issue number	6
DOIs	https://doi.org/10.3109/02770903.2014.903965
Publication status	Published - 2014 Aug

Keywords

Asian dust storms
Interleukin-8
Luciferase assay
Respiratory tract
THP-G8 cells

ASJC Scopus subject areas

Pediatrics, Perinatology, and Child Health
Immunology and Allergy
Pulmonary and Respiratory Medicine

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10.3109/02770903.2014.903965

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Watanabe, M., Kurai, J., Tomita, K., Sano, H., Abe, S., Saito, R., Minato, S., Igishi, T., Burioka, N., Sako, T., Yasuda, K., Mikami, M., Kurita, S., Tokuyasu, H., Ueda, Y., Konishi, T., Yamasaki, A., Aiba, S., Oshimura, M., & Shimizu, E. (2014). Effects on asthma and induction of interleukin-8 caused by Asian dust particles collected in western Japan. Journal of Asthma, 51(6), 595-602. https://doi.org/10.3109/02770903.2014.903965

Watanabe, M, Kurai, J, Tomita, K, Sano, H, Abe, S, Saito, R, Minato, S, Igishi, T, Burioka, N, Sako, T, Yasuda, K, Mikami, M, Kurita, S, Tokuyasu, H, Ueda, Y, Konishi, T, Yamasaki, A, Aiba, S, Oshimura, M & Shimizu, E 2014, 'Effects on asthma and induction of interleukin-8 caused by Asian dust particles collected in western Japan', Journal of Asthma, vol. 51, no. 6, pp. 595-602. https://doi.org/10.3109/02770903.2014.903965

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title = "Effects on asthma and induction of interleukin-8 caused by Asian dust particles collected in western Japan",

abstract = "Objective: Asian dust storms (ADS) contain various airborne particles that may augment airway inflammation by increasing the level of interleukin-8. The objective of the study was to investigate the association of exposure to an ADS with worsening of symptoms of adult asthma and the effect of ADS particles on interleukin-8 transcriptional activity. Methods: The subjects were 112 patients with mild to moderate asthma who recorded scores for their daily upper and lower respiratory tract symptoms and measured morning peak expiratory flow (PEF) from March to May 2011. Interleukin-8 transcriptional activity was assessed in THP-G8 cells that were exposed to airborne particles collected during days of ADS exposure. Results: Of the 112 patients, 31 had comorbid allergic rhinitis (AR) and/or chronic sinusitis (CS), and had worsened scores for upper respiratory tract symptoms on ADS days compared to non-ADS days. Scores for lower respiratory tract symptoms during ADS days were higher than non-ADS days in all patients. Three patients also had unscheduled hospital visits for exacerbation of asthma on ADS days. However, there was no significant difference in daily morning PEF between ADS and non-ADS days. Airborne particles collected on ADS days induced interleukin-8 transcriptional activity in THP-G8 cells compared to the original soil of the ADS. Conclusion: Exposure to an ADS aggravates upper and lower tract respiratory symptoms in patients with adult asthma. ADS airborne particles may increase airway inflammation through enhancement of interleukin-8 transcriptional activity.",

keywords = "Asian dust storms, Interleukin-8, Luciferase assay, Respiratory tract, THP-G8 cells",

author = "Masanari Watanabe and Jun Kurai and Katsuyuki Tomita and Hiroyuki Sano and Satoshi Abe and Rumiko Saito and Sayaka Minato and Tadashi Igishi and Naoto Burioka and Takanori Sako and Kazuhito Yasuda and Masaaki Mikami and Shinichi Kurita and Hirokazu Tokuyasu and Yasuto Ueda and Tatsuya Konishi and Akira Yamasaki and Setsuya Aiba and Mitsuo Oshimura and Eiji Shimizu",

note = "Funding Information: None of the authors have a conflict of interest regarding the work in this study. The authors alone are responsible for the content and writing of this article. This study was supported by the Environmental Research and Technology Development Fund (C-1154) of the Japanese Ministry of the Environment.",

year = "2014",

month = aug,

doi = "10.3109/02770903.2014.903965",

language = "English",

volume = "51",

pages = "595--602",

journal = "Journal of Asthma",

issn = "0277-0903",

publisher = "Informa Healthcare",

number = "6",

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TY - JOUR

T1 - Effects on asthma and induction of interleukin-8 caused by Asian dust particles collected in western Japan

AU - Watanabe, Masanari

AU - Kurai, Jun

AU - Tomita, Katsuyuki

AU - Sano, Hiroyuki

AU - Abe, Satoshi

AU - Saito, Rumiko

AU - Minato, Sayaka

AU - Igishi, Tadashi

AU - Burioka, Naoto

AU - Sako, Takanori

AU - Yasuda, Kazuhito

AU - Mikami, Masaaki

AU - Kurita, Shinichi

AU - Tokuyasu, Hirokazu

AU - Ueda, Yasuto

AU - Konishi, Tatsuya

AU - Yamasaki, Akira

AU - Aiba, Setsuya

AU - Oshimura, Mitsuo

AU - Shimizu, Eiji

N1 - Funding Information: None of the authors have a conflict of interest regarding the work in this study. The authors alone are responsible for the content and writing of this article. This study was supported by the Environmental Research and Technology Development Fund (C-1154) of the Japanese Ministry of the Environment.

PY - 2014/8

Y1 - 2014/8

N2 - Objective: Asian dust storms (ADS) contain various airborne particles that may augment airway inflammation by increasing the level of interleukin-8. The objective of the study was to investigate the association of exposure to an ADS with worsening of symptoms of adult asthma and the effect of ADS particles on interleukin-8 transcriptional activity. Methods: The subjects were 112 patients with mild to moderate asthma who recorded scores for their daily upper and lower respiratory tract symptoms and measured morning peak expiratory flow (PEF) from March to May 2011. Interleukin-8 transcriptional activity was assessed in THP-G8 cells that were exposed to airborne particles collected during days of ADS exposure. Results: Of the 112 patients, 31 had comorbid allergic rhinitis (AR) and/or chronic sinusitis (CS), and had worsened scores for upper respiratory tract symptoms on ADS days compared to non-ADS days. Scores for lower respiratory tract symptoms during ADS days were higher than non-ADS days in all patients. Three patients also had unscheduled hospital visits for exacerbation of asthma on ADS days. However, there was no significant difference in daily morning PEF between ADS and non-ADS days. Airborne particles collected on ADS days induced interleukin-8 transcriptional activity in THP-G8 cells compared to the original soil of the ADS. Conclusion: Exposure to an ADS aggravates upper and lower tract respiratory symptoms in patients with adult asthma. ADS airborne particles may increase airway inflammation through enhancement of interleukin-8 transcriptional activity.

AB - Objective: Asian dust storms (ADS) contain various airborne particles that may augment airway inflammation by increasing the level of interleukin-8. The objective of the study was to investigate the association of exposure to an ADS with worsening of symptoms of adult asthma and the effect of ADS particles on interleukin-8 transcriptional activity. Methods: The subjects were 112 patients with mild to moderate asthma who recorded scores for their daily upper and lower respiratory tract symptoms and measured morning peak expiratory flow (PEF) from March to May 2011. Interleukin-8 transcriptional activity was assessed in THP-G8 cells that were exposed to airborne particles collected during days of ADS exposure. Results: Of the 112 patients, 31 had comorbid allergic rhinitis (AR) and/or chronic sinusitis (CS), and had worsened scores for upper respiratory tract symptoms on ADS days compared to non-ADS days. Scores for lower respiratory tract symptoms during ADS days were higher than non-ADS days in all patients. Three patients also had unscheduled hospital visits for exacerbation of asthma on ADS days. However, there was no significant difference in daily morning PEF between ADS and non-ADS days. Airborne particles collected on ADS days induced interleukin-8 transcriptional activity in THP-G8 cells compared to the original soil of the ADS. Conclusion: Exposure to an ADS aggravates upper and lower tract respiratory symptoms in patients with adult asthma. ADS airborne particles may increase airway inflammation through enhancement of interleukin-8 transcriptional activity.

KW - Asian dust storms

KW - Interleukin-8

KW - Luciferase assay

KW - Respiratory tract

KW - THP-G8 cells

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Effects on asthma and induction of interleukin-8 caused by Asian dust particles collected in western Japan

Abstract

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