TY - JOUR
T1 - Efficacy of idebenone for respiratory failure in a patient with Leigh syndrome
T2 - A long-term follow-up study
AU - Haginoya, Kazuhiro
AU - Miyabayashi, Shigeaki
AU - Kikuchi, Masahiro
AU - Kojima, Akira
AU - Yamamoto, Katsuya
AU - Omura, Kiyoshi
AU - Uematsu, Mitsugu
AU - Hino-Fukuyo, Naomi
AU - Tanaka, Soichiro
AU - Tsuchiya, Shigeru
PY - 2009/3/15
Y1 - 2009/3/15
N2 - Respiratory failure can be the direct cause of death in patients with Leigh syndrome. Unfortunately, no effective treatment strategy is available. Here, we report successful treatment of a patient with Leigh syndrome using idebenone, a derivative of coenzyme Q-10. The patient's brainstem function, especially respiratory function, improved after idebenone treatment. Idebenone may be worth trying in patients with Leigh syndrome.
AB - Respiratory failure can be the direct cause of death in patients with Leigh syndrome. Unfortunately, no effective treatment strategy is available. Here, we report successful treatment of a patient with Leigh syndrome using idebenone, a derivative of coenzyme Q-10. The patient's brainstem function, especially respiratory function, improved after idebenone treatment. Idebenone may be worth trying in patients with Leigh syndrome.
KW - Idebenone
KW - Leigh syndrome
KW - Mitochondrial encephalopathy
KW - Respiratory failure
UR - http://www.scopus.com/inward/record.url?scp=58749085705&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=58749085705&partnerID=8YFLogxK
U2 - 10.1016/j.jns.2008.11.008
DO - 10.1016/j.jns.2008.11.008
M3 - Article
C2 - 19101701
AN - SCOPUS:58749085705
SN - 0022-510X
VL - 278
SP - 112
EP - 114
JO - Journal of the Neurological Sciences
JF - Journal of the Neurological Sciences
IS - 1-2
ER -