Efficient oxidative dehydrogenation of lactate to pyruvate using a gas-liquid micro flow system

Toshiya Yasukawa, Wataru Ninomiya, Ken Ooyachi, Nobuaki Aoki, Kazuhiro Mae

    Research output: Contribution to journalArticlepeer-review

    28 Citations (Scopus)


    An efficient production of pyruvate by the oxidative dehydrogenation of lactate is achieved using a micro flow system based on gas-liquid slug flow. In this micro flow system, oxidizing agents and acetonitrile solutions of lactates and vanadium species are used, and lactate is converted into the corresponding pyruvate. For reasons of atom economy and enhanced mass transfer of oxygen into the liquid phase, due to internal circulation flow within slugs, molecular oxygen is the preferred agent. In a catalyst screening, vanadium oxytrichloride (VOCl3) gave the highest pyruvate yield. A continuous system is developed, consisting of the following two processes using T-shaped mixers: the mixing of an acetonitrile solution of lactate with that of VOCl3 and the injection of oxygen gas into the solution mixture. Compared with the conventional batch system, the oxidative dehydrogenation of lactate to the corresponding pyruvate proceeds more effectively using this micro flow system.

    Original languageEnglish
    Pages (from-to)3858-3863
    Number of pages6
    JournalIndustrial and Engineering Chemistry Research
    Issue number7
    Publication statusPublished - 2011 Apr 6

    ASJC Scopus subject areas

    • Chemistry(all)
    • Chemical Engineering(all)
    • Industrial and Manufacturing Engineering


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