Efficient Use of Early Transition Metal, Titanium: Highly Selective Titanium Reagents

Koichi Mikami, Masahiro Terada, Takeshi Nakai

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12 Citations (Scopus)


The recent progress of highly selective titanium reagents in organic synthesis is reviewed. The use of titanium reagents is classified into the following six categories: (1) Bi-metallic reagents of titanium and main group elements, aluminum in particular, for olefination. (2) Alkyltitanium reagents for carbon-carbon bond formation. (3) Titanium enolates for aldol condensation. (4) Chiral titanium complexes for asymmetric Lewis-acid catalysis. (5) Low valent titanium reagents for reductive coupling reaction. (6) Sharpless reagent for asymmetric epoxidation.

Original languageEnglish
Pages (from-to)566-574
Number of pages9
JournalYuki Gosei Kagaku Kyokaishi/Journal of Synthetic Organic Chemistry
Issue number6
Publication statusPublished - 1991


  • Alkyltitanium reagents
  • Asymmetric catalysis
  • Chemoselectivity
  • Chiral titanium complexes
  • Coupling reaction
  • Diastereoselectivity
  • Diels-Alder reaction
  • Enantios-electivity
  • Ene reaction
  • Hetero bi-metallic reagents
  • Hydroalumination
  • Hydromagnesiation
  • Hydrotitanation
  • Kinetic resolution
  • Lewis acid
  • Low valent titanium reagents
  • Olefin methathesis
  • Olefination
  • Regioselectivity
  • Sharpless epoxidation
  • Stereoselectivity
  • Tebbe reagent
  • Titanium enolates


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