Electrochemical determination of choline using nortropine-N-oxyl for a non-enzymatic system

Yoshitomo Kashiwagi, Tetsuya Ono, Fumiya Sato, Masayuki Kumano, Kentaro Yoshida, Takenori Dairaku, Yusuke Sasano, Yoshiharu Iwabuchi, Katsuhiko Sato

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8 Citations (Scopus)


The electrocatalytical activity of nortropine-N-oxyl (NNO) was evaluated by cyclic voltammetry in pH 7.4 phosphate buffer solution. The anodic peak current for choline was enhanced in a concentration-dependent fashion, showing that choline was oxidized by the electrocatalytic effect of NNO. A high linear response to the choline concentration ranging from 0.1 to 10 mM was obtained. In contrast, 2,2,6,6-tetramethylpiperidine-N-oxyl (TEMPO) could not oxidize choline under the same conditions.

Original languageEnglish
Article number100302
JournalSensing and Bio-Sensing Research
Publication statusPublished - 2020 Feb


  • Choline
  • Electrocatalytic oxidation
  • Nitroxyl radical
  • Non-enzymatic system


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