Electrochemical Evaluation of Nitroxyl Radical Catalysts and Electrochemical Detection of Cyclosporin A

Sachiko Komatsu, Yusuke Sasano, Kyoko Sugiyama, Kazuhiro Watanabe, Masayuki Kumano, Kentaro Yoshida, Tetsuya Ono, Yoshiharu Iwabuchi, Tsutomu Fujimura, Katsuhiko Sato, Yoshitomo Kashiwagi

Research output: Contribution to journalArticlepeer-review

7 Citations (Scopus)


Nitroxyl radical catalysts oxidize alcohols under an applied electric potential. It is possible to quantify the alcohol concentration from the resulting oxidation current. In this work, we evaluated the catalytic activity of nitroxyl radicals (or their corresponding hydroxylamines), including 2,2,6,6- tetramethylpiperidine-1-oxyl (TEMPO) as representative nitroxyl radicals, acetoamido-TEMPO, which shows higher oxidation potential than TEMPO owing to the acetoamido group, AZADO, Nor-AZADO, and NNO as less-hindered bicyclic nitroxyl radicals, and NHPI as an N,N-diacyl-type hydroxylamine, in acetonitrile solution. TEMPO, AZADO and NNO were also evaluated for their ability to oxidize alcohols in organic solvents, and their reactivity was compared with the electrochemical response. The most active NNO was used for electrochemical detection of cyclosporin A, a drug with a hydroxyl group.An abstract stating the features and drawing attention to the novel aspects.

Original languageEnglish
Article number21027
Pages (from-to)1-9
Number of pages9
JournalInternational Journal of Electrochemical Science
Issue number2
Publication statusPublished - 2021 Feb


  • cyclosporine A
  • nitroxyl radical
  • sensor


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