TY - JOUR
T1 - Elevated adrenomedullin in the vitreous of patients with proliferative vitreoretinopathy
AU - Udono, Tetsuo
AU - Takahashi, Kazuhiro
AU - Takano, Shoko
AU - Shibahara, Shigeki
AU - Tamai, Makoto
PY - 1999/12
Y1 - 1999/12
N2 - PURPOSE: To explore the possible involvement of adrenomedullin in the pathophysiology of proliferative vitreoretinopathy. METHODS: The radioimmunoassay technique was used to determine immunoreactive adrenomedullin concentrations in the vitreous fluid from 41 eyes of 41 patients undergoing vitrectomy for a variety of retinal conditions, including proliferative vitreoretinopathy, proliferative diabetic retinopathy, age- related macular degeneration, and macular hole. RESULTS: Immunoreactive adrenomedullin levels in the vitreous of patients with proliferative vitreoretinopathy were significantly higher than those of patients with proliferative diabetic retinopathy (P < .005), age-related macular degeneration (P < .001), and macular hole (P < .0001). CONCLUSION: Adrenomedullin may be involved in the pathophysiology of proliferative vitreoretinopathy.
AB - PURPOSE: To explore the possible involvement of adrenomedullin in the pathophysiology of proliferative vitreoretinopathy. METHODS: The radioimmunoassay technique was used to determine immunoreactive adrenomedullin concentrations in the vitreous fluid from 41 eyes of 41 patients undergoing vitrectomy for a variety of retinal conditions, including proliferative vitreoretinopathy, proliferative diabetic retinopathy, age- related macular degeneration, and macular hole. RESULTS: Immunoreactive adrenomedullin levels in the vitreous of patients with proliferative vitreoretinopathy were significantly higher than those of patients with proliferative diabetic retinopathy (P < .005), age-related macular degeneration (P < .001), and macular hole (P < .0001). CONCLUSION: Adrenomedullin may be involved in the pathophysiology of proliferative vitreoretinopathy.
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U2 - 10.1016/S0002-9394(99)00247-0
DO - 10.1016/S0002-9394(99)00247-0
M3 - Article
C2 - 10612519
AN - SCOPUS:0033406171
SN - 0002-9394
VL - 128
SP - 765
EP - 767
JO - American Journal of Ophthalmology
JF - American Journal of Ophthalmology
IS - 6
ER -
