TY - JOUR
T1 - Enantioselective aza-Friedel-Crafts reaction catalyzed by a water inclusion complex of O,O′-diacyl tartaric acid
AU - Ube, Hitoshi
AU - Fukuchi, Satoko
AU - Terada, Masahiro
PY - 2010/5/17
Y1 - 2010/5/17
N2 - The efficiency of an O,O′-diacyl tartaric acid derivative as a chiral Brønsted acid catalyst was investigated in the enantioselective Friedel-Crafts reaction of indoles with an α-imino ester. The inclusion of water in the O,O′-di-p-toluoyl-d-tartaric acid catalyst is crucial for obtaining the enantioselectivity, and under optimal conditions the corresponding Friedel-Crafts product was obtained with an enantioselectivity of up to 88% ee.
AB - The efficiency of an O,O′-diacyl tartaric acid derivative as a chiral Brønsted acid catalyst was investigated in the enantioselective Friedel-Crafts reaction of indoles with an α-imino ester. The inclusion of water in the O,O′-di-p-toluoyl-d-tartaric acid catalyst is crucial for obtaining the enantioselectivity, and under optimal conditions the corresponding Friedel-Crafts product was obtained with an enantioselectivity of up to 88% ee.
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U2 - 10.1016/j.tetasy.2010.04.012
DO - 10.1016/j.tetasy.2010.04.012
M3 - Article
AN - SCOPUS:77956696328
SN - 0957-4166
VL - 21
SP - 1203
EP - 1205
JO - Tetrahedron Asymmetry
JF - Tetrahedron Asymmetry
IS - 9-10
ER -