Enantioselective Friedel-Crafts reaction of electron-rich alkenes catalyzed by chiral Brønsted acid

Masahiro Terada; Keiichi Sorimachi

doi:10.1021/ja0678166

Enantioselective Friedel-Crafts reaction of electron-rich alkenes catalyzed by chiral Brønsted acid

Masahiro Terada, Keiichi Sorimachi

SCI - Chemistry

Tohoku University

Research output: Contribution to journal › Article › peer-review

312 Citations (Scopus)

Abstract

We present the first enantioselective catalysis of the Friedel-Crafts reaction via activation of electron-rich multiple bonds by a chiral Brønsted acid. The reaction of various indole derivatives with a broad range of substituted enecarbamates affords the corresponding Friedel-Crafts products in high yield and enantioselectivity.

Original language	English
Pages (from-to)	292-293
Number of pages	2
Journal	Journal of the American Chemical Society
Volume	129
Issue number	2
DOIs	https://doi.org/10.1021/ja0678166
Publication status	Published - 2007 Jan 17

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abstract = "We present the first enantioselective catalysis of the Friedel-Crafts reaction via activation of electron-rich multiple bonds by a chiral Br{\o}nsted acid. The reaction of various indole derivatives with a broad range of substituted enecarbamates affords the corresponding Friedel-Crafts products in high yield and enantioselectivity.",

author = "Masahiro Terada and Keiichi Sorimachi",

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AU - Sorimachi, Keiichi

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N2 - We present the first enantioselective catalysis of the Friedel-Crafts reaction via activation of electron-rich multiple bonds by a chiral Brønsted acid. The reaction of various indole derivatives with a broad range of substituted enecarbamates affords the corresponding Friedel-Crafts products in high yield and enantioselectivity.

AB - We present the first enantioselective catalysis of the Friedel-Crafts reaction via activation of electron-rich multiple bonds by a chiral Brønsted acid. The reaction of various indole derivatives with a broad range of substituted enecarbamates affords the corresponding Friedel-Crafts products in high yield and enantioselectivity.

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Enantioselective Friedel-Crafts reaction of electron-rich alkenes catalyzed by chiral Brønsted acid

Abstract

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